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Estimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritance

dc.contributor.authorHasstedt, Sandra J.en_US
dc.contributor.authorMoll, Patricia P.en_US
dc.contributor.authorRao, D. C.en_US
dc.date.accessioned2013-12-04T18:57:42Z
dc.date.available2013-12-04T18:57:42Z
dc.date.issued1989en_US
dc.identifier.citationHasstedt, Sandra J.; Moll, Patricia P.; Rao, D. C. (1989). "Estimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritance." Genetic Epidemiology 6(2): 319-332. <http://hdl.handle.net/2027.42/101835>en_US
dc.identifier.issn0741-0395en_US
dc.identifier.issn1098-2272en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/101835
dc.description.abstractA major locus that is detected through its effect on one phenotype (a primary trait) may also affect other quantitative phenotypes or qualitative disease endpoints (secondary traits). The pattern of effects for the mutant allele. The effects are directly estimable when “measured genotypes” or a tightly linked marker allow unambiguous assignment of major locus genotypes. When genotype assignments are ambiguous for a major locus detected through its effect on a quantitative primary trait, we propose estimators using genotypic probabilities. Making certain reasonable assumptions, we demonstrate asymptotic unbiasedness of these genotypic probability estimators of the genotypic means and variances for either the quantitative primary or secondary traits, of the covariances between quantitative primary and secondary traits, and of prevalences for the secondary qualitative traits. An important application of genotypic probability estimators is to define an effect of a major locus that cannot be detected upon analysis of the variable; for example, major locus effects may be defined for hypertension or blood pressure as secondary traits, but not detected as primary traits.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherMaximum Likelihood Estimatorsen_US
dc.subject.otherLikelihood Analysisen_US
dc.subject.otherGenotypic Probability Estimatorsen_US
dc.subject.otherPleiotropic Gene Effectsen_US
dc.subject.otherBivariate Phenotypesen_US
dc.titleEstimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritanceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Epidemiology and Human Genetics, University of Michigan, Ann Arboren_US
dc.contributor.affiliationotherDepartment of Human Genetics, University of Utah, Salt Lake Cityen_US
dc.identifier.pmid2721927en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/101835/1/1370060203_ftp.pdf
dc.identifier.doi10.1002/gepi.1370060203en_US
dc.identifier.sourceGenetic Epidemiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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