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T‐cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection
dc.contributor.authorClayton, Linda K.en_US
dc.contributor.authorGhendler, Yosephen_US
dc.contributor.authorMizoguchi, Emikoen_US
dc.contributor.authorPatch, Raymond J.en_US
dc.contributor.authorOcain, Timothy D.en_US
dc.contributor.authorOrth, Kimen_US
dc.contributor.authorBhan, Atul K.en_US
dc.contributor.authorDixit, Vishva M.en_US
dc.contributor.authorReinherz, Ellis L.en_US
dc.date.accessioned2014-01-08T20:34:14Z
dc.date.available2014-01-08T20:34:14Z
dc.date.issued1997-05-01en_US
dc.identifier.citationClayton, Linda K.; Ghendler, Yoseph; Mizoguchi, Emiko; Patch, Raymond J.; Ocain, Timothy D.; Orth, Kim; Bhan, Atul K.; Dixit, Vishva M.; Reinherz, Ellis L. (1997). "T‐cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection." The EMBO Journal 16(9): 2282-2293. <http://hdl.handle.net/2027.42/102045>en_US
dc.identifier.issn0261-4189en_US
dc.identifier.issn1460-2075en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/102045
dc.publisherJohn Wiley & Sons, Ltden_US
dc.subject.otherThymusen_US
dc.subject.otherNegative Selectionen_US
dc.subject.otherCaspaseen_US
dc.subject.otherApoptosisen_US
dc.titleT‐cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selectionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid9171343en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102045/1/emboj7590216.pdf
dc.identifier.doi10.1093/emboj/16.9.2282en_US
dc.identifier.sourceThe EMBO Journalen_US
dc.identifier.citedreferenceSentman CL, Shutter JR, Hockenbery D, Kanagawa O and Korsmeyer SJ ( 1991 ) bcl‐2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67, 879 – 888.en_US
dc.identifier.citedreferenceShi Y, Bissonnette RP, Parfrey N, Szalay M, Kubo RT and Green DR ( 1991 ) In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol, 146, 3340 – 3346.en_US
dc.identifier.citedreferenceShinkai Y et al. ( 1992 ) Rag‐2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell, 68, 855 – 867.en_US
dc.identifier.citedreferenceSleath PR, Hendrickson RC, Kronheim SR, March CJ and Black RA ( 1990 ) Substrate specificity of the protease that processes human interleukin‐β. J Biol Chem, 265, 14526 – 14528.en_US
dc.identifier.citedreferenceSmith CA, Williams GT, Kingston R, Jenkinson EJ and Owen JJ ( 1989 ) Antibodies to CD3/T cell receptor complex induce death by apoptosis in immature T cells in thymic culture. Nature, 337, 181 – 184.en_US
dc.identifier.citedreferenceSmith KGC, Strasser A and Vaux DL ( 1996 ) CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO‐1)‐transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease. EMBO J, 15, 5167 – 5176.en_US
dc.identifier.citedreferenceSteglich W and Hofle G ( 1969 ) N, N ‐dimethyl‐4‐pyridinamine, a very effective acylation catalyst. Angew Chem, Int Ed Engl, 8, 981.en_US
dc.identifier.citedreferenceSteller H ( 1995 ) Mechanisms and genes of cellular suicide. Science, 267, 1445 – 1449.en_US
dc.identifier.citedreferenceSurh CD and Sprent J ( 1994 ) T cell apoptosis detected in situ during positive and negative selection in the thymus. Nature, 372, 100 – 103.en_US
dc.identifier.citedreferenceTakahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T and Nagata S ( 1994 ) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76, 969 – 976.en_US
dc.identifier.citedreferenceTartaglia LA, Ayres TM, Wong GHW and Goeddel DV ( 1993 ) A novel domain within the 55 kDa TNF receptor signals cell death. Cell, 74, 845 – 853.en_US
dc.identifier.citedreferenceTewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS and Dixit VM ( 1995 ) Yama/CPP32 β, a mammalian homolog of CED‐3, is a CrmA‐inhibitable protease that cleaves the death substrate poly(ADPribose) polymerase. Cell, 81, 801 – 809.en_US
dc.identifier.citedreferenceThornberry NA et al. ( 1992 ) A novel heterodimeric cysteine protease is required for interleukin‐1β processing in monocytes. Nature, 356, 768 – 774.en_US
dc.identifier.citedreferenceThornberry NA, Peterson EP, Zhao JJ, Howard AD, Griffin PR and Chapman KT ( 1994 ) Inactivation of interleukin‐1β converting enzyme by peptide (acyloxy)methyl ketones. Biochemistry, 33, 3934 – 3940.en_US
dc.identifier.citedreferenceTrauth BC, Klas C, Peters AM, Matzku S, Moller P, Falk W, Debatin KM and Krammer PH ( 1989 ) Monoclonal antibody‐mediated tumor regression by induction of apoptosis. Science, 245, 301 – 305.en_US
dc.identifier.citedreferenceVasquez NJ, Kaye J and Hedrick SM ( 1992 ) In vivo and in vitro clonal deletion of double positive thymocytes. J Exp Med, 175, 1307 – 1316.en_US
dc.identifier.citedreferenceVaux DL ( 1993 ) Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA, 90, 786 – 789.en_US
dc.identifier.citedreferenceVaux DL and Strasser A ( 1996 ) The molecular biology of apoptosis. Proc Natl Acad Sci USA, 93, 2239 – 2244.en_US
dc.identifier.citedreferenceVaux DL, Aguila HL and Weissman IL ( 1992 ) Bcl‐2 prevents death of factor‐deprived cells but fails to prevent apoptosis in targets of cell mediated killing. Int Immunol, 4, 821.en_US
dc.identifier.citedreferenceWalker NPC et al. ( 1994 ) Crystal structure of the cysteine protease interleukin‐1β‐converting enzyme: a (p20/p10) 2 homodimer. Cell, 78, 343 – 352.en_US
dc.identifier.citedreferenceWang S, Miura M, Jung Y, Zhu H, Gagliardini V, Shi L, Greenberg AH and Yuan J ( 1996 ) Identification and characterization of Ich‐3, a member of the interleukin‐1β converting enzyme (ICE)/Ced‐3 family and an upstream regulator of ICE. J Biol Chem, 271, 20580 – 20587.en_US
dc.identifier.citedreferenceWilson KP et al. ( 1994 ) Structure and mechanism of interleukin‐β converting enzyme. Nature, 370, 270 – 275.en_US
dc.identifier.citedreferenceWyllie AH ( 1980 ) Glucocorticoid induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature, 284, 555 – 556.en_US
dc.identifier.citedreferenceYang E and Korsmeyer SJ ( 1996 ) Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood, 88, 386 – 401.en_US
dc.identifier.citedreferenceYonehara S, Ishii A and Yonehara M ( 1989 ) A cell‐killing monoclonal antibody (anti‐Fas) to a cell surface antigen co‐downregulated with the receptor of tumor necrosis factor. J Exp Med, 169, 1747 – 1756.en_US
dc.identifier.citedreferenceAlderson MR, Tough TW, Braddy S, Davis ST, Roux E, Schooley K, Miller RE and Lynch DH ( 1994 ) Regulation of apoptosis and T cell activation by Fas‐specific mAb. Int Immunol, 6, 1799 – 1806.en_US
dc.identifier.citedreferenceAlnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J ( 1996 ) Human ICE/CED‐3 protease nomenclature. Cell, 87, 171.en_US
dc.identifier.citedreferenceAmakawa R et al. ( 1996 ) Impaired negative selection of T cells in Hodgkin's disease antigen CD30‐deficient mice. Cell, 84, 551 – 562.en_US
dc.identifier.citedreferenceAshton‐Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM and Tonegawa S ( 1994 ) Evidence for a differential avidity model of T cell selection in the thymus. Cell, 76, 651 – 663.en_US
dc.identifier.citedreferenceBarlos K, Chatzi O, Gatos D and Stavropoulos G ( 1991 ) 2‐chlorotrityl chloride resin: studies on anchoring of Fmoc‐amino acids and peptide cleavage. Int J Pept Protein Res, 37, 513 – 520.en_US
dc.identifier.citedreferenceBecker MLB, Near R, Mudgett‐Hunter M, Margolies MN, Kubo RT, Kaye J and Hedrick SM ( 1989 ) Expression of a hybrid immunoglobulin T cell receptor protein in transgenic mice. Cell, 58, 911 – 921.en_US
dc.identifier.citedreferenceBluestone JA ( 1995 ) New Perspectives of CD28‐B7‐mediated T cell costimulation. Immunity, 2, 555 – 559.en_US
dc.identifier.citedreferenceCaputo A, James MNG, Powers JC, Hudig D and Bleackley RC ( 1994 ) Conversion of the substrate specificity of mouse proteinase granzyme B. Nature Struct Biol, 1, 364 – 367.en_US
dc.identifier.citedreferenceCarpino LA ( 1993 ) 1‐Hydroxy‐7‐azabenzotriazole: an efficient peptide coupling additive. J Am Chem Soc, 115, 4397 – 4398.en_US
dc.identifier.citedreferenceCarpino LA, El‐Faham A, Minor CA and Albericio F ( 1994 ) Advantageous applications of azabenzotriazole (triazolopyridine)‐based coupling reagents to solid phase peptide synthesis. J Chem Soc Chem Commun, 201 – 203.en_US
dc.identifier.citedreferenceChang H‐C et al. ( 1994 ) A general method for facilitating heterodimeric pairing between two proteins: application to expression of α and β T cell receptor extracellular segments. Proc Natl Acad Sci USA, 91, 11408 – 11412.en_US
dc.identifier.citedreferenceChapman KT ( 1992 ) Synthesis of a potent, reversible inhibitor of interleukin‐1β converting enzyme. Bioorg Med Chem Lett, 2, 613 – 618.en_US
dc.identifier.citedreferenceChinnaiyan AM, O'Rourke K, Yu G‐L, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J and Dixit VM ( 1996a ) Signal transduction by DR3, a death domain‐containing receptor related to TNFR‐1 and CD95. Science, 274, 990 – 992.en_US
dc.identifier.citedreferenceChinnaiyan AM, Tepper CG, Seldin MF, O'Rourke K, Kishkel FC, Hellbardt S, Krammer PH, Peter ME and Dixit VM ( 1996b ) FADD/MORT1 is a common mediator of CD95 (Fas/APO‐1) and tumor necrosis factor receptor‐induced apoptosis. J Biol Chem, 271, 4961 – 4965.en_US
dc.identifier.citedreferenceChinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG and Dixit VM ( 1996c ) Molecular ordering of the cell death pathway: Bcl–2 and Bcl‐x L function upstream of the CED‐3‐like apoptotic proteases. J Biol Chem, 271, 4373 – 4576.en_US
dc.identifier.citedreferenceColigan JE, Kruisbeek AM, Margulies DH, Shevach EM and Strober W ( 1994 ) Current Protocols in Immunology John Wiley & Sons, New York.en_US
dc.identifier.citedreferenceCrispe IN ( 1994 ) Fatal interactions: Fas‐induced apoptosis of immature T cells. Immunity, 1, 347 – 349.en_US
dc.identifier.citedreferenceDarmon AJ, Nicholson DW and Bleackley RC ( 1995 ) Activation of the apoptotic protease CPP‐32 by cytotoxic T cell‐derived granzyme B. Nature, 377, 446 – 448.en_US
dc.identifier.citedreferenceDegermann S, Surh CD, Glimcher LH, Sprent J and Lo D ( 1994 ) B7 expression on thymic medullary epithelium correlates with epithelium‐mediated deletion of Vβ5+ thymocytes. J Immunol, 152, 3254 – 3263.en_US
dc.identifier.citedreferenceDolle RE, Hoyer D, Prasad CV, Schmidt SJ, Helaszek CT, Miller RE and Ator MA ( 1994a ) P1 aspartate‐based peptide α‐((2,6‐dichlorobenzoyl)oxy)methyl ketones as potent time‐dependent inhibitors of interleukin‐1β‐converting enzyme. J Med Chem, 37, 563 – 564.en_US
dc.identifier.citedreferenceDolle RE et al. ( 1994b ) Aspartyl α‐((1‐phenyl‐3(trifluoromethyl)‐pyrazol‐5‐yl)osy)methyl ketones as interleukin‐1β‐converting enzyme inhibitors: significance of the P1 and P3 amino nitrogens for enzyme‐peptide inhibitor binding. J Med Chem, 37, 3863 – 3866.en_US
dc.identifier.citedreferenceDuan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW and Dixit VM ( 1996a ) ICE‐LAP6, a novel member of the ICE/Ced‐3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem, 271, 16720 – 16724.en_US
dc.identifier.citedreferenceDuan H, Chinnaiyan AM, Hudson PL, Wing JP, He WW and Dixit VM ( 1996b ) ICE‐LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced‐3 is activated during Fas‐ and tumor necrosis factor‐induced apoptosis. J Biol Chem, 271, 1621 – 1625.en_US
dc.identifier.citedreferenceFearnhead HO, Dinsdale D and Cohen GM ( 1995 ) An interleukin‐1β converting enzyme‐like protease is a common mediator of apoptosis in thymocytes. FEBS Lett, 375, 283 – 288.en_US
dc.identifier.citedreferenceFernandes‐Alnemri T et al. ( 1996 ) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease and a substrate for granzyme B. Proc Natl Acad Sci USA, 93, 7464 – 7469.en_US
dc.identifier.citedreferenceFowlkes BJ and Pardoll DM ( 1989 ) Molecular and cellular events of T cell development. Adv Immunol, 44, 207 – 264.en_US
dc.identifier.citedreferenceFowlkes BJ, Schwartz RH and Pardoll DM ( 1988 ) Deletion of self‐reactive thymocytes occurs at a CD4 + 8 + precursor stage. Nature, 334, 620 – 623.en_US
dc.identifier.citedreferenceGavrieli Y, Sherman Y and Ben‐Sasson SA ( 1992 ) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol, 119, 493 – 501.en_US
dc.identifier.citedreferenceHanson RD and Ley TJ ( 1990 ) Transcriptional activation of the human cytotoxic serine protease gene CSP‐B in T lymphocytes. Mol Cell Biol, 10, 5655 – 5662.en_US
dc.identifier.citedreferenceHanson RD, Sclar GM, Kanagawa O and Ley TJ ( 1991 ) The 5′ flanking region of the human CGL‐1/granzyme B gene targets expression of a reporter gene to activated T lymphocytes in transgenic mice. J Biol Chem, 266, 24433 – 24438.en_US
dc.identifier.citedreferenceHenkart PA ( 1996 ) ICE family proteases: mediators of all apoptotic cell death? Immunity, 4, 195 – 201.en_US
dc.identifier.citedreferenceHeusel JW, Hanson RD, Silverman GA and Ley TJ ( 1991 ) Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. J Biol Chem, 266, 61l52 – 6158.en_US
dc.identifier.citedreferenceHogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ and Carbone FR ( 1994 ) T cell receptor antagonist peptides induce positive selection. Cell, 76, 17 – 27.en_US
dc.identifier.citedreferenceHoward AD et al. ( 1991 ) IL‐1 converting enzyme requires aspartic acid residues for processing of the IL‐1β precursor at two distinct sites and does not cleave 31‐kDa IL‐1α. J Immunol, 147, 2964 – 2969.en_US
dc.identifier.citedreferenceItoh N and Nagata S ( 1993 ) A novel protein domain required for apoptosis: mutational analysis of human Fas antigen. J Biol Chem, 268, 10932 – 10937.en_US
dc.identifier.citedreferenceKappler JW, Roehm N and Marrack P ( 1987 ) T cell tolerance by clonal elimination in the thymus. Cell, 49, 273 – 280.en_US
dc.identifier.citedreferenceKisielow P, Bluthmann H, Staerz UD, Steinmetz M and von Boehmer H ( 1988 ) Tolerance in T cell receptor transgenic mice involves deletion of nonmature CD4 + CD8 + thymocytes. Nature, 333, 742 – 746.en_US
dc.identifier.citedreferenceKrantz A, Copp LJ, Coles PJ, Smith RA and Heard SB ( 1991 ) Peptidyl(acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases. Biochemistry, 30, 4678 – 4687.en_US
dc.identifier.citedreferenceKuida K, Lippke JA, Ku G, Harding MW and Livingston DJ, Su MS‐S, Flavell RA ( 1995 ) Altered cytokine export and apoptosis in mice deficient in interleukin‐1β converting enzyme. Science, 267, 2000 – 2003.en_US
dc.identifier.citedreferenceKuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P and Flavell RA ( 1996 ) Decreased apoptosis in the brain and premature lethality in CPP32‐deficient mice. Nature, 384, 368 – 372.en_US
dc.identifier.citedreferenceLerner A, Clayton LK, Mizoguchi E, Ghendler Y, von Ewik W, Koyasu S, Bhan AK and Reinherz EL ( 1996 ) Cross‐linking of T‐cell receptors on double‐positive thymocytes induces a cytokine‐mediated stromal activation process linked to cell death. EMBO J, 15, 5876 – 5877.en_US
dc.identifier.citedreferenceLi P et al. ( 1995 ) Mice deficient in IL‐1β‐converting enzyme are defective in production of mature IL‐1β and resistant to endotoxic shock. Cell, 80, 401 – 411.en_US
dc.identifier.citedreferenceMizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler AC and Bhan AK ( 1996 ) Cytokine imbalance and autoantibody production in T cell receptor α mutant mice and inflammatory bowel disease. J Exp Med, 183, 847 – 856.en_US
dc.identifier.citedreferenceMombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK and Tonegawa S ( 1993 ) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell, 75, 275 – 282.en_US
dc.identifier.citedreferenceMurphy KM, Heimberger AB and Loh DY ( 1990 ) Induction by antigen of intrathymic apoptosis of CD4 + CD8 + TCR low thymocytes in vivo. Science, 250, 1720 – 1723.en_US
dc.identifier.citedreferenceMurphy MEP, Moult J, Bleackley RC, Gershenfeld H, Weissman IL and James MNG ( 1988 ) Comparative molecular model building of two serine proteases from cytotoxic T lymphocytes. Proteins Struct Funct Genet, 4, 190 – 204.en_US
dc.identifier.citedreferenceMuzio M et al. ( 1996 ) FLICE, a novel FADD‐homologous ICE/CED‐3‐like protease, is recruited to the CD95 (Fas/APO‐1) death‐inducing signaling complex. Cell, 85, 817 – 827.en_US
dc.identifier.citedreferenceNalin CM ( 1995 ) Apoptosis research enters the ICE age. Structure, 3, 143 – 145.en_US
dc.identifier.citedreferenceNicholson DW et al. ( 1995 ) Identification and inhibition of the ICE/CED‐3 protease necessary for mammalian apoptosis. Nature, 376, 37 – 43.en_US
dc.identifier.citedreferenceNossal GJV ( 1994 ) Negative selection of lymphocytes. Cell, 76, 229 – 239.en_US
dc.identifier.citedreferenceOdake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J and Powers JC ( 1991 ) Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry, 30, 2217 – 2227.en_US
dc.identifier.citedreferenceOrth K, Chinnaiyan AM, Garg M, Froelich CJ and Dixit VM ( 1996a ) The CED‐3/ICE‐like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem, 271, 16443 – 16446.en_US
dc.identifier.citedreferenceOrth K, O'Rourke K, Salvesen GS and Dixit VM ( 1996b ) Molecular ordering of apoptotic mammalian CED‐3/ICE‐like proteases. J Biol Chem, 271, 20977 – 20980.en_US
dc.identifier.citedreferencePage DM, Kane LP, Allison JP and Hedrick SM ( 1993 ) Two signals are required for negative selection of CD4 + CD8 + thymocytes. J Immunol, 151, 1868 – 1880.en_US
dc.identifier.citedreferencePatten PA, Rock EP, Sonoda T, Fazekas de St Groth B, Jorgensen JL and Davis MM ( 1993 ) Transfer of putative complementarity‐determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity. J Immunol, 150, 2281 – 2294.en_US
dc.identifier.citedreferencePronk GJ, Ramer K, Amiri P and Williams LT ( 1996 ) Requirement of an ICE‐like protease for induction of apoptosis and ceramide generation by REAPER. Science, 271, 808 – 810.en_US
dc.identifier.citedreferencePunt JA, Osborne BA, Takahama Y, Sharrow SO and Singer A ( 1994 ) Negative selection of CD4 + CD8 + thymocytes by T cell receptor‐induced apoptosis requires a costimulatory signal that can be provided by CD28. J Exp Med, 179, 709 – 713.en_US
dc.identifier.citedreferenceQuan LT, Tewari M, O'Rourke K, Dixit VM, Snipas SJ, Poirier GG, Ray C, Pickup DJ and Salvesen GS ( 1996 ) Proteolytic activation of the cell death protease Yama/CPP‐32 by granzyme B. Proc Natl Acad Sci USA, 93, 1972 – 1976.en_US
dc.identifier.citedreferenceRamarli D, Fox DA and Reinherz EL ( 1987 ) Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci USA, 84, 8598 – 8602.en_US
dc.identifier.citedreferenceRotonda J et al. ( 1996 ) The three dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nature Struct Biol, 3, 619 – 625.en_US
dc.identifier.citedreferenceRozzo AJ, Eisenberg RA, Cohen PL and Kotzin BL ( 1994 ) Development of the T cell receptor repertoire in lpr mice. Semin Immunol, 6, 19 – 26.en_US
dc.identifier.citedreferenceSarin A, Wu M‐L and Henkart PA ( 1996 ) Different interleukin‐1β converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli. J Exp Med, 184, 2445 – 2450.en_US
dc.identifier.citedreferenceSchlegel J, Peters I, Orrenius S, Miller DK, Thornberry NA, Yamin T‐T and Nicholson DW ( 1996 ) CPP‐32/apopain is the key interleukin‐1β‐converting enzyme‐like protease involved in Fas‐mediated apoptosis. J Biol Chem, 271, 1841 – 1844.en_US
dc.identifier.citedreferenceSebzda E, Wallace VA, Mayer J, Yeung RS, Mak TW and Ohashi PS ( 1994 ) Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science, 263, 1615 – 1618.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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