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The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea

dc.contributor.authorGage, Philip J.en_US
dc.contributor.authorKuang, Chenen_US
dc.contributor.authorZacharias, Amanda L.en_US
dc.date.accessioned2014-11-04T16:35:11Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-11-04T16:35:11Z
dc.date.issued2014-11en_US
dc.identifier.citationGage, Philip J.; Kuang, Chen; Zacharias, Amanda L. (2014). "The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea." Developmental Dynamics 243(11): 1391-1400.en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/109268
dc.publisherAcademic Pressen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherCanonical Wnt Signalingen_US
dc.subject.otherDkk2en_US
dc.subject.otherGlaucomaen_US
dc.subject.otherOcular Anterior Segmenten_US
dc.subject.otherTemporal Gene Knockouten_US
dc.titleThe homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing corneaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/109268/1/dvdy24165.pdf
dc.identifier.doi10.1002/dvdy.24165en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
dc.identifier.citedreferencePressman CL, Chen H, Johnson RL. 2000. LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye. Genesis 26: 15 – 25.en_US
dc.identifier.citedreferenceSuh H, Gage PJ, Drouin J, Camper SA. 2002. Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development 129: 329 – 337.en_US
dc.identifier.citedreferenceKidson SH, Kume T, Deng K, Winfrey V, Hogan BL. 1999. The forkhead/winged‐helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol 211: 306 – 322.en_US
dc.identifier.citedreferenceLe Douarin NM. 1980. Migration and differentiation of neural crest cells. In: Moscona A, Monroy A, editors. Current topics in development, part II. New York: Academic Press.en_US
dc.identifier.citedreferenceLe Lievre CS, Le Douarin NM. 1975. Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos. J Embryol Exp Morphol 34: 125 – 154.en_US
dc.identifier.citedreferenceLehmann OJ, Ebenezer ND, Jordan T, Fox M, Ocaka L, Payne A, Leroy BP, Clark BJ, Hitchings RA, Povey S, Khaw PT, Bhattacharya SS. 2000. Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma. Am J Hum Genet 67: 1129 – 1135.en_US
dc.identifier.citedreferenceLi X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, Hurley M, Guo C, Boskey A, Sun L, Harris SE, Rowe DW, Ke HZ, Wu D. 2005. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet 37: 945 – 952.en_US
dc.identifier.citedreferenceLiu CY, Shiraishi A, Kao CW, Converse RL, Funderburgh JL, Corpuz LM, Conrad GW, Kao WW. 1998. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. J Biol Chem 273: 22584 – 22588.en_US
dc.identifier.citedreferenceLiu H, Mohamed O, Dufort D, Wallace VA. 2003. Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev Dyn 227: 323 – 334.en_US
dc.identifier.citedreferenceMartin DM, Skidmore JM, Fox SE, Gage PJ, Camper SA. 2002. Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium. Dev Biol 252: 84 – 99.en_US
dc.identifier.citedreferenceMatt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB. 2005. Retinoic acid‐dependent eye morphogenesis is orchestrated by neural crest cells. Development 132: 4789 – 4800.en_US
dc.identifier.citedreferenceMcintosh I, Dreyer SD, Clough MV, Dunston JA, Eyaid W, Roig CM, Montgomery T, Ala‐Mello S, Kaitila I, Winterpacht A, Zabel B, Frydman M, Cole WG, Francomano CA, Lee B. 1998. Mutation analysis of LMX1B gene in nail‐patella syndrome patients. Am J Hum Genet 63: 1651 – 1658.en_US
dc.identifier.citedreferenceMolotkov A, Molotkova N, Duester G. 2006. Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. Development 133: 1901 – 1910.en_US
dc.identifier.citedreferencePearton DJ, Yang Y, Dhouailly D. 2005. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals. Proc Natl Acad Sci USA 102: 3714 – 3719.en_US
dc.identifier.citedreferenceChow RL, Lang RA. 2001. Early eye development in vertebrates. Annu Rev Cell Dev Biol 17: 255 – 296.en_US
dc.identifier.citedreferenceRuzankina Y, Pinzon‐Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ. 2007. Deletion of the developmentally essential gene ATR in adult mice leads to age‐related phenotypes and stem cell loss. Cell Stem Cell 1: 113 – 126.en_US
dc.identifier.citedreferenceSaika S, Liu CY, Azhar M, Sanford LP, Doetschman T, Gendron RL, Kao CW, Kao WW. 2001. TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol 240: 419 – 432.en_US
dc.identifier.citedreferenceSemina EV, Reiter R, Leysens NJ, Alward WL, Small KW, Datson NA, Siegel‐Bartelt J, Bierke‐Nelson D, Bitoun P, Zabel BU, Carey JC, Murray JC. 1996. Cloning and characterization of a novel bicoid‐related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet 14: 392 – 399.en_US
dc.identifier.citedreferenceSeo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T. 2012. Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci USA 109: 2015 – 2020.en_US
dc.identifier.citedreferenceThut CJ, Rountree RB, Hwa M, Kingsley DM. 2001. A large‐scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol 231: 63 – 76.en_US
dc.identifier.citedreferenceVollrath D, Jaramillo‐Babb VL, Clough MV, Mcintosh I, Scott KM, Lichter PR, Richards JE. 1998. Loss‐of‐function mutations in the LIM‐homeodomain gene, LMX1B, in nail‐patella syndrome. Hum Mol Genet 7: 1091 – 1098.en_US
dc.identifier.citedreferenceZacharias AL, Lewandoski M, Rudnicki MA, Gage PJ. 2011. Pitx2 is an upstream activator of extraocular myogenesis and survival. Dev Biol 349: 395 – 405.en_US
dc.identifier.citedreferenceZhao S, Chen Q, Hung FC, Overbeek PA. 2002. BMP signaling is required for development of the ciliary body. Development 129: 4435 – 4442.en_US
dc.identifier.citedreferenceAsai‐Coakwell M, Backhouse C, Casey RJ, Gage PJ, Lehmann OJ. 2006. Reduced human and murine corneal thickness in an Axenfeld‐Rieger syndrome subtype. Invest Ophthalmol Vis Sci 47: 4905 – 4909.en_US
dc.identifier.citedreferenceCushman LJ, Watkins‐Chow DE, Brinkmeier ML, Raetzman LT, Radak AL, Lloyd RV, Camper SA. 2001. Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. Hum Mol Genet 10: 1141 – 1153.en_US
dc.identifier.citedreferenceCvekl A, Tamm ER. 2004. Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases. Bioessays 26: 374 – 386.en_US
dc.identifier.citedreferenceEvans AL, Gage PJ. 2005a. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet 14: 3347 – 3359.en_US
dc.identifier.citedreferenceEvans AL, Gage PJ. 2005b. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Human Mol Genet 14: 3347 – 3359.en_US
dc.identifier.citedreferenceGage PJ, Suh H, Camper SA. 1999. Dosage requirement of Pitx2 for development of multiple organs. Development 126: 4643 – 4651.en_US
dc.identifier.citedreferenceGage PJ, Rhoades W, Prucka SK, Hjalt TA. 2005. Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci 46: 4200 – 4208.en_US
dc.identifier.citedreferenceGage PJ, Qian M, Wu D, Rosenberg KI. 2008. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 317: 310 – 324.en_US
dc.identifier.citedreferenceGovindarajan V, Ito M, Makarenkova HP, Lang RA, Overbeek PA. 2000. Endogenous and ectopic gland induction by FGF‐10. Dev Biol 225: 188 – 200.en_US
dc.identifier.citedreferenceGruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. 2007. Acute postnatal ablation of Hif‐2alpha results in anemia. Proc Natl Acad Sci USA 104: 2301 – 2306.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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