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Viral load, gene expression and mapping of viral integration sites in HPV16‐associated HNSCC cell lines

dc.contributor.authorOlthof, Nadine C.en_US
dc.contributor.authorHuebbers, Christian U.en_US
dc.contributor.authorKolligs, Juttaen_US
dc.contributor.authorHenfling, Miekeen_US
dc.contributor.authorRamaekers, Frans C.S.en_US
dc.contributor.authorCornet, Irisen_US
dc.contributor.authorLent‐albrechts, Josefa A.en_US
dc.contributor.authorStegmann, Alexander P.A.en_US
dc.contributor.authorSilling, Steffien_US
dc.contributor.authorWieland, Ulrikeen_US
dc.contributor.authorCarey, Thomas E.en_US
dc.contributor.authorWalline, Heather M.en_US
dc.contributor.authorGollin, Susanne M.en_US
dc.contributor.authorHoffmann, Thomas K.en_US
dc.contributor.authorWinter, Johanen_US
dc.contributor.authorKremer, Bernden_US
dc.contributor.authorKlussmann, Jens P.en_US
dc.contributor.authorSpeel, Ernst‐jan M.en_US
dc.date.accessioned2015-01-07T15:23:25Z
dc.date.available2016-05-10T20:26:29Zen
dc.date.issued2015-03-01en_US
dc.identifier.citationOlthof, Nadine C.; Huebbers, Christian U.; Kolligs, Jutta; Henfling, Mieke; Ramaekers, Frans C.S.; Cornet, Iris; Lent‐albrechts, Josefa A. ; Stegmann, Alexander P.A.; Silling, Steffi; Wieland, Ulrike; Carey, Thomas E.; Walline, Heather M.; Gollin, Susanne M.; Hoffmann, Thomas K.; Winter, Johan; Kremer, Bernd; Klussmann, Jens P.; Speel, Ernst‐jan M. (2015). "Viral load, gene expression and mapping of viral integration sites in HPV16â associated HNSCC cell lines." International Journal of Cancer 136(5): E207-E218.en_US
dc.identifier.issn0020-7136en_US
dc.identifier.issn1097-0215en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/109861
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherAPOT‐PCRen_US
dc.subject.otherDIPS‐PCRen_US
dc.subject.otherIntegrationen_US
dc.subject.otherViral Integrationen_US
dc.subject.otherGenetic Localizationen_US
dc.titleViral load, gene expression and mapping of viral integration sites in HPV16‐associated HNSCC cell linesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/109861/1/ijc29112.pdf
dc.identifier.doi10.1002/ijc.29112en_US
dc.identifier.sourceInternational Journal of Canceren_US
dc.identifier.citedreferenceHafkamp HC, Manni JJ, Haesevoets A, et al. Marked differences in survival rate between smokers and nonsmokers with HPV 16‐associated tonsillar carcinomas. Int J Cancer 2008; 122: 2656 – 64.en_US
dc.identifier.citedreferenceSaunier M, Monnier‐Benoit S, Mauny F, et al. Analysis of human papillomavirus type 16 (HPV16) DNA load and physical state for identification of HPV16‐infected women with high‐grade lesions or cervical carcinoma. J Clin Microbiol 2008; 46: 3678 – 85.en_US
dc.identifier.citedreferenceHafkamp HC, Speel EJ, Haesevoets A, et al. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5–8. Int J Cancer 2003; 107: 394 – 400.en_US
dc.identifier.citedreferenceMellin H, Dahlgren L, Munck‐Wikland E, et al. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer 2002; 102: 152 – 8.en_US
dc.identifier.citedreferenceKoskinen WJ, Chen RW, Leivo I, et al. Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck. Int J Cancer 2003; 107: 401 – 6.en_US
dc.identifier.citedreferenceBegum S, Cao D, Gillison M, et al. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res 2005; 11: 5694 – 9.en_US
dc.identifier.citedreferenceChang YE, Pena L, Sen GC, et al. Long‐term effect of interferon on keratinocytes that maintain human papillomavirus type 31. J Virol 2002; 76: 8864 – 74.en_US
dc.identifier.citedreferenceHerdman MT, Pett MR, Roberts I, et al. Interferon‐beta treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants. Carcinogenesis 2006; 27: 2341 – 53.en_US
dc.identifier.citedreferenceWhite JS, Weissfeld JL, Ragin CCR, et al. The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines. Oral Oncol 2007; 43: 701 – 12.en_US
dc.identifier.citedreferenceBalló H, Koldovsky P, Hoffmann T, et al. Establishment and characterization of four cell lines derived from human head and neck squamous cell carcinomas for an autologous tumor‐fibroblast in vitro model. Anticancer Res 1999; 19: 3827 – 36.en_US
dc.identifier.citedreferenceSteenbergen RD, Hermsen MA, Walboomers JM, et al. Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line. Cancer Res 1995; 55: 5465 – 71.en_US
dc.identifier.citedreferenceBouvard V, Storey A, Pim D, et al. Characterization of the human papillomavirus E2 protein: evidence of trans‐activation and trans‐repression in cervical keratinocytes. EMBO J 1994; 13: 5451 – 9.en_US
dc.identifier.citedreferencede Roda Husman AM, Walboomers JM, van den Brule AJ, et al. The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 1995; 76(Pt 4): 1057 – 62.en_US
dc.identifier.citedreferenceWeissenborn SJ, Funke AM, Hellmich M, et al. Oncogenic human papillomavirus DNA loads in human immunodeficiency virus‐positive women with high‐grade cervical lesions are strongly elevated. J Clin Microbiol 2003; 41: 2763 – 7.en_US
dc.identifier.citedreferenceWeissenborn SJ, Wieland U, Junk M, et al. Quantification of beta‐human papillomavirus DNA by real‐time PCR. Nat Protoc 2010; 5: 1 – 13.en_US
dc.identifier.citedreference.Map Viewer. Available at: http://www.ncbi.nlm.nih.gov/mapview. Accessed on 15 September 2013.en_US
dc.identifier.citedreferenceHopman AHN, Smedts F, Dignef W, et al. Transition of high‐grade cervical intraepithelial neoplasia to micro‐invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J Pathol 2004; 202: 23 – 33.en_US
dc.identifier.citedreferenceOlthof NC, Speel E‐JM, Kolligs J, et al. Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS One 2014; 9: e88718.en_US
dc.identifier.citedreferenceSmedts F, Schrik M, Horn T, et al. Diagnostic value of processing cytologic aspirates of renal tumors in agar cell (tissue) blocks. Acta Cytol 2010; 54: 587 – 94.en_US
dc.identifier.citedreferenceLopez JR, Claessen SMH, Macville MVE, et al. Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON‐1. Neuroendocrinology 2010; 91: 131 – 41.en_US
dc.identifier.citedreference.Basic Logical Alignment Search Tool (BLAST). Available at: http://blast.ncbi.nlm.nih.gov. Accessed on 13 September 2013.en_US
dc.identifier.citedreferenceLuft F, Klaes R, Nees M, et al. Detection of integrated papillomavirus sequences by ligation‐mediated PCR (DIPS‐PCR) and molecular characterization in cervical cancer cells. Int J Cancer 2001; 92: 9 – 17.en_US
dc.identifier.citedreferenceGanguly N, Parihar SP. Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis. J Biosci 2009; 34: 113 – 23.en_US
dc.identifier.citedreferenceNarisawa‐Saito M, Kiyono T. Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci. 2007; 98: 1505 – 11.en_US
dc.identifier.citedreferenceRagin CCR, Reshmi SC, Gollin SM. Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line. Int J Cancer 2004; 110: 701 – 9.en_US
dc.identifier.citedreferenceAkagi K, Li J, Broutian TR, et al. Genome‐wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res 2014; 24: 185 – 99.en_US
dc.identifier.citedreferenceLace MJ, Anson JR, Klussmann JP, et al. Human papillomavirus type 16 (HPV‐16) genomes integrated in head and neck cancers and in HPV‐16‐immortalized human keratinocyte clones express chimeric virus‐cell mRNAs similar to those found in cervical cancers. J Virol 2011; 85: 1645 – 54.en_US
dc.identifier.citedreferenceHuebbers CU, Preuss SF, Kolligs J, et al. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile‐onset laryngeal papillomatosis. PLoS One 2013; 8: e57207.en_US
dc.identifier.citedreferenceWiest T, Schwarz E, Enders C, et al. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 2002; 21: 1510 – 7.en_US
dc.identifier.citedreferenceYoshida T, Sano T, Oyama T, et al. Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. Virchows Archiv 2009; 455: 253 – 9.en_US
dc.identifier.citedreferenceLi H, Yang Y, Zhang R, et al. Preferential sites for the integration and disruption of human papillomavirus 16 in cervical lesions. J Clin Virol 2013; 56: 342 – 7.en_US
dc.identifier.citedreferencede Boer MA, Jordanova ES, Kenter GG, et al. High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients. Clin Cancer Res 2007; 13: 132 – 8.en_US
dc.identifier.citedreferenceGammoh N, Grm HS, Massimi P, et al. Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activator. J Virol 2006; 80: 1787 – 97.en_US
dc.identifier.citedreferenceReimers N, Kasper HU, Weissenborn SJ, et al. Combined analysis of HPV‐DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 2007; 120: 1731 – 8.en_US
dc.identifier.citedreferenceKumar B, Cordell KG, Lee JS, et al. EGFR, p16, HPV Titer, Bcl‐xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol 2008; 26: 3128 – 37.en_US
dc.identifier.citedreferenceKlussmann JP, Weissenborn SJ, Wieland U, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001; 92: 2875 – 84.en_US
dc.identifier.citedreferenceD'Souza G, Kreimer AR, Viscidi R, et al. Case‐control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356: 1944 – 56.en_US
dc.identifier.citedreferenceRagin CCR, Modugno F, Gollin SM. The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J Dent Res 2007; 86: 104 – 14.en_US
dc.identifier.citedreferenceOlthof NC, Straetmans JM, Snoeck R, Ramaekers FC, Kremer B, Speel EJ. Next‐generation treatment strategies for human papillomavirus‐related head and neck squamous cell carcinoma: where do we go? Rev Med Virol 2011; 22: 88 – 105.en_US
dc.identifier.citedreferenceLassen P, Eriksen JG, Hamilton‐Dutoit S, et al. HPV‐associated p16‐expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol 2010; 94: 30 – 5.en_US
dc.identifier.citedreferenceMaxwell JH, Kumar B, Feng FY, et al. Tobacco use in human papillomavirus‐positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 2010; 16: 1226 – 35.en_US
dc.identifier.citedreferenceAng KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24 – 35.en_US
dc.identifier.citedreferenceMooren JJ, Kremer B, Claessen SMH, et al. Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis. Int J Cancer 2013; 132: 1781 – 9.en_US
dc.identifier.citedreferenceTheelen W, Speel EJM, Herfs M, et al. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA‐assay. Am J Pathol 2010; 177: 2022 – 33.en_US
dc.identifier.citedreferenceKlaes R, Woerner SM, Ridder R, et al. Detection of high‐risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999; 59: 6132 – 6.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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