Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model
dc.contributor.author | Arnold, Alan A | |
dc.contributor.author | Aboukameel, Amro | |
dc.contributor.author | Chen, Jianyong | |
dc.contributor.author | Yang, Dajun | |
dc.contributor.author | Wang, Shaomeng | |
dc.contributor.author | Al-Katib, Ayad | |
dc.contributor.author | Mohammad, Ramzi M | |
dc.date.accessioned | 2015-08-07T17:42:56Z | |
dc.date.available | 2015-08-07T17:42:56Z | |
dc.date.issued | 2008-02-14 | |
dc.identifier.citation | Molecular Cancer. 2008 Feb 14;7(1):20 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/112761 | en_US |
dc.description.abstract | Abstract Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting Bcl-2 family proteins, Apogossypolone (ApoG2) using follicular small cleaved cell lymphoma cell line (WSU-FSCCL) and cell isolated from lymphoma patients. ApoG2 inhibited the growth of WSU-FSCCL significantly with a 50% growth inhibition of cells (IC50) of 109 nM and decreased cell number of fresh lymphoma cells. ApoG2 activated caspases-9, -3, and -8, and the cleavage of Poly (ADP-ribose) polymerase (PARP) and Apoptosis Inducing Factor (AIF). In the WSU-FSCCL-SCID xenograft model, ApoG2 showed a significant anti-lymphoma effect, with %ILS of 84% in the intravenous and 63% in intraperitoneal treated mice. These studies suggest that ApoG2 can be an effective therapeutic agent against FL. | |
dc.title | Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/112761/1/12943_2007_Article_311.pdf | |
dc.identifier.doi | 10.1186/1476-4598-7-20 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Arnold et al. | |
dc.date.updated | 2015-08-07T17:42:57Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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