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Development of Enantioselective Palladium‐Catalyzed Alkene Carboalkoxylation Reactions for the Synthesis of Tetrahydrofurans

dc.contributor.authorHopkins, Brett A.en_US
dc.contributor.authorGarlets, Zachary J.en_US
dc.contributor.authorWolfe, John P.en_US
dc.date.accessioned2015-11-12T21:04:15Z
dc.date.available2017-01-03T16:21:17Zen
dc.date.issued2015-11-02en_US
dc.identifier.citationHopkins, Brett A.; Garlets, Zachary J.; Wolfe, John P. (2015). "Development of Enantioselective Palladium‐Catalyzed Alkene Carboalkoxylation Reactions for the Synthesis of Tetrahydrofurans." Angewandte Chemie 127(45): 13588-13590.en_US
dc.identifier.issn0044-8249en_US
dc.identifier.issn1521-3757en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/115959
dc.description.abstractThe Pd‐catalyzed coupling of γ‐hydroxyalkenes with aryl bromides affords enantiomerically enriched 2‐(arylmethyl)tetrahydrofuran derivatives in good yield and up to 96:4 e.r. This transformation was achieved through the development of a new TADDOL/2‐arylcyclohexanol‐derived chiral phosphite ligand. The transformations are effective with an array of different aryl bromides, and can be used for the preparation of products bearing quaternary stereocenters.Der Aufbau von enantiomerenangereicherten Tetrahydrofuranen gelingt durch die asymmetrische Pd‐katalysierte Kreuzkupplung zwischen γ‐Hydroxyalkenen und Arylbromiden. Der Palladiumkatalysator, der einen neuen chiralen TADDOL‐Phosphitliganden trägt, liefert die Produkte in guten Ausbeuten mit bis zu 96:4 e.r. (siehe Schema).en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherAsymmetrische Katalyseen_US
dc.subject.otherEnantioselektive Syntheseen_US
dc.subject.otherHeterocyclenen_US
dc.subject.otherPalladiumen_US
dc.titleDevelopment of Enantioselective Palladium‐Catalyzed Alkene Carboalkoxylation Reactions for the Synthesis of Tetrahydrofuransen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, 930. N. University Ave, Ann Arbor, MI 48109‐1055 (USA)en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/115959/1/ange_201506884_sm_miscellaneous_information.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/115959/2/13588_ftp.pdf
dc.identifier.doi10.1002/ange.201506884en_US
dc.identifier.sourceAngewandte Chemieen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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