Dentin Sialophosphoprotein: A Regulatory Protein for Dental Pulp Stem Cell Identity and Fate
dc.contributor.author | Guo, Shiliang | |
dc.contributor.author | Lim, Dandrich | |
dc.contributor.author | Dong, Zhihong | |
dc.contributor.author | Saunders, Thomas L. | |
dc.contributor.author | Ma, Peter X. | |
dc.contributor.author | Marcelo, Cynthia L. | |
dc.contributor.author | Ritchie, Helena H. | |
dc.date.accessioned | 2017-12-19T21:15:37Z | |
dc.date.available | 2017-12-19T21:15:37Z | |
dc.date.issued | 2014-07-15 | |
dc.identifier.citation | Guo, Shiliang; Lim, Dandrich; Dong, Zhihong; Saunders, Thomas L.; Ma, Peter X.; Marcelo, Cynthia L.; Ritchie, Helena H. (2014). "Dentin Sialophosphoprotein: A Regulatory Protein for Dental Pulp Stem Cell Identity and Fate." Stem Cells and Development 23 (23): 2883-2894. | |
dc.identifier.issn | 1547-3287 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/140203 | |
dc.description.abstract | The dentin sialophosphoprotein (dspp) transcript is expressed during tooth development as a DSPP precursor protein, which then undergoes cleavage to form mature dentin sialoprotein (DSP) and phosphophoryn (PP) proteins. Previous studies using DSPP-knockout (KO) mice have reported that these animals have hypomineralized teeth, thin dentin, and a large dental pulp chamber, similar to those from patients with dentinogenesis imperfecta III. However, there is no information about factors that regulate dental pulp stem cell lineage fate, a critical early event in the odontoblast-dentin mineralization scheme. To reveal the role of DSPP in odontoblast lineage differentiation during tooth development, we systematically examined teeth from wild-type (wt) and DSPP-KO C57BL/6 mice between the ages of postnatal day 1 and 3 months. We found developmental abnormalities not previously reported, such as circular dentin formation within dental pulp cells and altered odontoblast differentiation in DSPP-KO mice, even as early as 1 day after birth. Surprisingly, we also identified chondrocyte-like cells in the dental pulp from KO-mice teeth. Thus, these studies that compare wt and DSPP-KO mice suggest that the expression of DSPP precursor protein is required for normal odontoblast lineage differentiation and that the absence of DSPP allows dental pulp cells to differentiate into chondrocyte-like cells, which could negatively impact pulpal wound healing and tissue regeneration. | |
dc.publisher | Mary Ann Liebert, Inc., publishers | |
dc.title | Dentin Sialophosphoprotein: A Regulatory Protein for Dental Pulp Stem Cell Identity and Fate | |
dc.type | Article | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/140203/1/scd.2014.0066.pdf | |
dc.identifier.doi | 10.1089/scd.2014.0066 | |
dc.identifier.source | Stem Cells and Development | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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