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Effect of chitinase- 3- like protein 1 on glucose metabolism: In vitro skeletal muscle and human genetic association study
dc.contributor.authorKwak, So‐young
dc.contributor.authorSeo, Il Hyeok
dc.contributor.authorChung, InHyeok
dc.contributor.authorKim, Shin Ae
dc.contributor.authorLee, Jung Ok
dc.contributor.authorLee, Hye Jeong
dc.contributor.authorKim, Sung Eun
dc.contributor.authorHan, Jeong Ah
dc.contributor.authorKang, Min Ju
dc.contributor.authorKim, Su Jin
dc.contributor.authorLim, Soo
dc.contributor.authorKim, Kyoung Min
dc.contributor.authorChung, Ji Hyung
dc.contributor.authorLim, Eunice
dc.contributor.authorHwang, Jong‐ik
dc.contributor.authorKim, Hyeon Soo
dc.contributor.authorShin, Min‐jeong
dc.date.accessioned2020-10-01T23:31:27Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-10-01T23:31:27Z
dc.date.issued2020-10
dc.identifier.citationKwak, So‐young ; Seo, Il Hyeok; Chung, InHyeok; Kim, Shin Ae; Lee, Jung Ok; Lee, Hye Jeong; Kim, Sung Eun; Han, Jeong Ah; Kang, Min Ju; Kim, Su Jin; Lim, Soo; Kim, Kyoung Min; Chung, Ji Hyung; Lim, Eunice; Hwang, Jong‐ik ; Kim, Hyeon Soo; Shin, Min‐jeong (2020). "Effect of chitinase- 3- like protein 1 on glucose metabolism: In vitro skeletal muscle and human genetic association study." The FASEB Journal (10): 13445-13460.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/162777
dc.description.abstractWe investigated the effect of chitinase- 3- like protein 1 (CHI3L1) on glucose metabolism and its underlying mechanisms in skeletal muscle cells, and evaluated whether the observed effects are relevant in humans. CHI3L1 was associated with increased glucose uptake in skeletal muscles in an AMP- activated protein kinase (AMPK)- dependent manner, and with increased intracellular calcium levels via PAR2. The improvement in glucose metabolism observed in an intraperitoneal glucose tolerance test on male C57BL/6J mice supported this association. Inhibition of the CaMKK was associated with suppression of CHI3L1- mediated glucose uptake. Additionally, CHI3L1 was found to influence glucose uptake through the PI3K/AKT pathway. Results suggested that CHI3L1 stimulated the phosphorylation of AS160 and p38 MAPK downstream of AMPK and AKT, and the resultant GLUT4 translocation. In primary myoblast cells, stimulation of AMPK and AKT was observed in response to CHI3L1, underscoring the biological relevance of CHI3L1. CHI3L1 levels were elevated in cells under conditions that mimic exercise in vitro and in exercised mice in vivo, indicating that CHI3L1 is secreted during muscle contraction. Finally, similar associations between CHI3L1 and metabolic parameters were observed in humans alongside genotype associations between CHI3L1 and diabetes at the population level. CHI3L1 may be a potential therapeutic target for the treatment of diabetes.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherAMPK
dc.subject.otherChitinase- 3- like protein 1
dc.subject.otherglucose metabolism
dc.subject.otherglucose uptake
dc.subject.othermyokine
dc.titleEffect of chitinase- 3- like protein 1 on glucose metabolism: In vitro skeletal muscle and human genetic association study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/162777/2/fsb220907.pdfen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/162777/1/fsb220907_am.pdfen_US
dc.identifier.doi10.1096/fj.202000925R
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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