Ascertainment of vaccination status by self-report versus source documentation: Impact on measuring COVID-19 vaccine effectiveness
Stephenson, Meagan; Olson, Samantha M.; Self, Wesley H.; Ginde, Adit A.; Mohr, Nicholas M.; Gaglani, Manjusha; Shapiro, Nathan I.; Gibbs, Kevin W.; Hager, David N.; Prekker, Matthew E.; Gong, Michelle N.; Steingrub, Jay S.; Peltan, Ithan D.; Martin, Emily T.; Reddy, Raju; Busse, Laurence W.; Duggal, Abhijit; Wilson, Jennifer G.; Qadir, Nida; Mallow, Christopher; Kwon, Jennie H.; Exline, Matthew C.; Chappell, James D.; Lauring, Adam S.; Baughman, Adrienne; Lindsell, Christopher J.; Hart, Kimberly W.; Lewis, Nathaniel M.; Patel, Manish M.; Tenforde, Mark W.
2022-11
Citation
Stephenson, Meagan; Olson, Samantha M.; Self, Wesley H.; Ginde, Adit A.; Mohr, Nicholas M.; Gaglani, Manjusha; Shapiro, Nathan I.; Gibbs, Kevin W.; Hager, David N.; Prekker, Matthew E.; Gong, Michelle N.; Steingrub, Jay S.; Peltan, Ithan D.; Martin, Emily T.; Reddy, Raju; Busse, Laurence W.; Duggal, Abhijit; Wilson, Jennifer G.; Qadir, Nida; Mallow, Christopher; Kwon, Jennie H.; Exline, Matthew C.; Chappell, James D.; Lauring, Adam S.; Baughman, Adrienne; Lindsell, Christopher J.; Hart, Kimberly W.; Lewis, Nathaniel M.; Patel, Manish M.; Tenforde, Mark W. (2022). "Ascertainment of vaccination status by self-report versus source documentation: Impact on measuring COVID-19 vaccine effectiveness." Influenza and Other Respiratory Viruses 16(6): 1101-1111.
Abstract
BackgroundDuring the COVID-19 pandemic, self-reported COVID-19 vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available. We evaluated the concordance of COVID-19 vaccination status ascertained by self-report versus source documentation and its impact on VE estimates.MethodsHospitalized adults (≥18 years) admitted to 18 U.S. medical centers March–June 2021 were enrolled, including COVID-19 cases and SARS-CoV-2 negative controls. Patients were interviewed about COVID-19 vaccination. Abstractors simultaneously searched IIS, medical records, and other sources for vaccination information. To compare vaccination status by self-report and documentation, we estimated percent agreement and unweighted kappa with 95% confidence intervals (CIs). We then calculated VE in preventing COVID-19 hospitalization of full vaccination (2 doses of mRNA product ≥14 days prior to illness onset) independently using data from self-report or source documentation.ResultsOf 2520 patients, 594 (24%) did not have self-reported vaccination information to assign vaccination group; these patients tended to be more severely ill. Among 1924 patients with both self-report and source documentation information, 95.0% (95% CI: 93.9–95.9%) agreement was observed, with a kappa of 0.9127 (95% CI: 0.9109–0.9145). VE was 86% (95% CI: 81–90%) by self-report data only and 85% (95% CI: 81-89%) by source documentation data only.ConclusionsApproximately one-quarter of hospitalized patients could not provide self-report COVID-19 vaccination status. Among patients with self-report information, there was high concordance with source documented status. Self-report may be a reasonable source of COVID-19 vaccination information for timely VE assessment for public health action.Publisher
Wiley Periodicals, Inc. Centers for Disease Control and Prevention
ISSN
1750-2640 1750-2659
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