Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation
dc.contributor.author | Kazemi, A | |
dc.contributor.author | Louis, B | |
dc.contributor.author | Isabey, D | |
dc.contributor.author | Nieman, GF | |
dc.contributor.author | Gatto, LA | |
dc.contributor.author | Satalin, J | |
dc.contributor.author | Baker, S | |
dc.contributor.author | Grotberg, JB | |
dc.contributor.author | Filoche, M | |
dc.contributor.editor | McCulloch, Andrew D | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2022-12-01T21:00:36Z | |
dc.date.available | 2022-12-01T21:00:36Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.issn | 1553-7358 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/31622332 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/175166 | en |
dc.description.abstract | Surfactant Replacement Therapy (SRT), which involves instillation of a liquid-surfactant mixture directly into the lung airway tree, is a major therapeutic treatment in neonatal patients with respiratory distress syndrome (RDS). This procedure has proved to be remarkably effective in premature newborns, inducing a five-fold decrease of mortality in the past 35 years. Disappointingly, its use in adults for treating acute respiratory distress syndrome (ARDS) experienced initial success followed by failures. Our recently developed numerical model has demonstrated that transition from success to failure of SRT in adults could, in fact, have a fluid mechanical origin that is potentially reversible. Here, we present the first numerical simulations of surfactant delivery into a realistic asymmetric conducting airway tree of the rat lung and compare them with experimental results. The roles of dose volume (VD), flow rate, and multiple aliquot delivery are investigated. We find that our simulations of surfactant delivery in rat lungs are in good agreement with our experimental data. In particular, we show that the monopodial architecture of the rat airway tree plays a major role in surfactant delivery, contributing to the poor homogeneity of the end distribution of surfactant. In addition, we observe that increasing VD increases the amount of surfactant delivered to the acini after losing a portion to coating the involved airways, the coating cost volume, VCC. Finally, we quantitatively assess the improvement resulting from a multiple aliquot delivery, a method sometimes employed clinically, and find that a much larger fraction of surfactant reaches the alveolar regions in this case. This is the first direct qualitative and quantitative comparison of our numerical model with experimental studies, which enhances our previous predictions in adults and neonates while providing a tool for predicting, engineering, and optimizing patient-specific surfactant delivery in complex situations. | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.relation.haspart | ARTN e1007408 | |
dc.rights | Licence for published version: Creative Commons Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Animals | |
dc.subject | Computer Simulation | |
dc.subject | Hydrodynamics | |
dc.subject | Lung | |
dc.subject | Maximal Expiratory Flow Rate | |
dc.subject | Models, Anatomic | |
dc.subject | Models, Statistical | |
dc.subject | Pulmonary Surfactants | |
dc.subject | Rats | |
dc.subject | Rats, Long-Evans | |
dc.subject | Rats, Sprague-Dawley | |
dc.subject | Rats, Wistar | |
dc.subject | Surface-Active Agents | |
dc.title | Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation | |
dc.type | Article | |
dc.identifier.pmid | 31622332 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175166/2/Surfactant delivery in rat lungs Comparing 3D geometrical simulation model with experimental instillation.pdf | |
dc.identifier.doi | 10.1371/journal.pcbi.1007408 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6626 | |
dc.identifier.source | PLoS Computational Biology | |
dc.description.version | Published version | |
dc.date.updated | 2022-12-01T21:00:30Z | |
dc.identifier.orcid | 0000-0001-7917-2451 | |
dc.description.filedescription | Description of Surfactant delivery in rat lungs Comparing 3D geometrical simulation model with experimental instillation.pdf : Published version | |
dc.identifier.volume | 15 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | e1007408 | |
dc.identifier.name-orcid | Kazemi, A | |
dc.identifier.name-orcid | Louis, B | |
dc.identifier.name-orcid | Isabey, D | |
dc.identifier.name-orcid | Nieman, GF | |
dc.identifier.name-orcid | Gatto, LA | |
dc.identifier.name-orcid | Satalin, J | |
dc.identifier.name-orcid | Baker, S | |
dc.identifier.name-orcid | Grotberg, JB; 0000-0001-7917-2451 | |
dc.identifier.name-orcid | Filoche, M | |
dc.working.doi | 10.7302/6626 | en |
dc.owningcollname | Biomedical Engineering, Department of |
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