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Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

dc.contributor.authorLi, Guoping
dc.contributor.authorChen, Tianji
dc.contributor.authorDahlman, James
dc.contributor.authorEniola-Adefeso, Lola
dc.contributor.authorGhiran, Ionita C.
dc.contributor.authorKurre, Peter
dc.contributor.authorLam, Wilbur A.
dc.contributor.authorLang, Jennifer K.
dc.contributor.authorMarbán, Eduardo
dc.contributor.authorMartín, Pilar
dc.contributor.authorMomma, Stefan
dc.contributor.authorMoos, Malcolm
dc.contributor.authorNelson, Deborah J.
dc.contributor.authorRaffai, Robert L.
dc.contributor.authorRen, Xi
dc.contributor.authorSluijter, Joost P. G.
dc.contributor.authorStott, Shannon L.
dc.contributor.authorVunjak-Novakovic, Gordana
dc.contributor.authorWalker, Nykia D.
dc.contributor.authorWang, Zhenjia
dc.contributor.authorWitwer, Kenneth W.
dc.contributor.authorYang, Phillip C.
dc.contributor.authorLundberg, Martha S.
dc.contributor.authorOchocinska, Margaret J.
dc.contributor.authorWong, Renee
dc.contributor.authorZhou, Guofei
dc.contributor.authorChan, Stephen Y.
dc.contributor.authorDas, Saumta
dc.contributor.authorSundd, Prithu
dc.date.accessioned2023-03-03T21:09:38Z
dc.date.available2024-03-03 16:09:36en
dc.date.available2023-03-03T21:09:38Z
dc.date.issued2023-02
dc.identifier.citationLi, Guoping; Chen, Tianji; Dahlman, James; Eniola-Adefeso, Lola ; Ghiran, Ionita C.; Kurre, Peter; Lam, Wilbur A.; Lang, Jennifer K.; Marbán, Eduardo ; Martín, Pilar ; Momma, Stefan; Moos, Malcolm; Nelson, Deborah J.; Raffai, Robert L.; Ren, Xi; Sluijter, Joost P. G.; Stott, Shannon L.; Vunjak-Novakovic, Gordana ; Walker, Nykia D.; Wang, Zhenjia; Witwer, Kenneth W.; Yang, Phillip C.; Lundberg, Martha S.; Ochocinska, Margaret J.; Wong, Renee; Zhou, Guofei; Chan, Stephen Y.; Das, Saumta; Sundd, Prithu (2023). "Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases." Journal of Extracellular Vesicles 12(2): n/a-n/a.
dc.identifier.issn2001-3078
dc.identifier.issn2001-3078
dc.identifier.urihttps://hdl.handle.net/2027.42/175910
dc.description.abstractExtracellular vesicles (EVs) carry diverse bioactive components including nucleic acids, proteins, lipids and metabolites that play versatile roles in intercellular and interorgan communication. The capability to modulate their stability, tissue-specific targeting and cargo render EVs as promising nanotherapeutics for treating heart, lung, blood and sleep (HLBS) diseases. However, current limitations in large-scale manufacturing of therapeutic-grade EVs, and knowledge gaps in EV biogenesis and heterogeneity pose significant challenges in their clinical application as diagnostics or therapeutics for HLBS diseases. To address these challenges, a strategic workshop with multidisciplinary experts in EV biology and U.S. Food and Drug Administration (USFDA) officials was convened by the National Heart, Lung and Blood Institute. The presentations and discussions were focused on summarizing the current state of science and technology for engineering therapeutic EVs for HLBS diseases, identifying critical knowledge gaps and regulatory challenges and suggesting potential solutions to promulgate translation of therapeutic EVs to the clinic. Benchmarks to meet the critical quality attributes set by the USFDA for other cell-based therapeutics were discussed. Development of novel strategies and approaches for scaling-up EV production and the quality control/quality analysis (QC/QA) of EV-based therapeutics were recognized as the necessary milestones for future investigations.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherHeart, lung, blood and sleep (HLBS) diseases
dc.subject.othertherapeutics and diagnostics
dc.subject.otherextracellular vesicles (EVs)
dc.titleCurrent challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175910/1/jev212305_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175910/2/jev212305.pdf
dc.identifier.doi10.1002/jev2.12305
dc.identifier.sourceJournal of Extracellular Vesicles
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