Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients
dc.contributor.author | Morrison, RJ | |
dc.contributor.author | Hollister, SJ | |
dc.contributor.author | Niedner, MF | |
dc.contributor.author | Mahani, MG | |
dc.contributor.author | Park, AH | |
dc.contributor.author | Mehta, DK | |
dc.contributor.author | Ohye, RG | |
dc.contributor.author | Green, GE | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-01-09T17:06:24Z | |
dc.date.available | 2024-01-09T17:06:24Z | |
dc.date.issued | 2015-04-29 | |
dc.identifier.issn | 1946-6234 | |
dc.identifier.issn | 1946-6242 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/25925683 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/191960 | en |
dc.description.abstract | Three-dimensional (3D) printing offers the potential for rapid customization of medical devices. The advent of 3D-printable biomaterials has created the potential for device control in the fourth dimension: 3D-printed objects that exhibit a designed shape change under tissue growth and resorption conditions over time. Tracheobronchomalacia (TBM) is a condition of excessive collapse of the airways during respiration that can lead to life-threatening cardiopulmonary arrests. We demonstrate the successful application of 3D printing technology to produce a personalized medical device for treatment of TBM, designed to accommodate airway growth while preventing external compression over a predetermined time period before bioresorption. We implanted patient-specific 3D-printed external airway splints in three infants with severe TBM. At the time of publication, these infants no longer exhibited life-threatening airway disease and had demonstrated resolution of both pulmonary and extrapulmonary complications of their TBM. Long-term data show continued growth of the primary airways. This process has broad application for medical manufacturing of patient-specific 3D-printed devices that adjust to tissue growth through designed mechanical and degradation behaviors over time. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | American Association for the Advancement of Science (AAAS) | |
dc.relation.haspart | ARTN 285ra64 | |
dc.subject | Child | |
dc.subject | Equipment and Supplies | |
dc.subject | Humans | |
dc.subject | Precision Medicine | |
dc.subject | Printing, Three-Dimensional | |
dc.subject | Tracheobronchomalacia | |
dc.title | Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients | |
dc.type | Article | |
dc.identifier.pmid | 25925683 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/191960/2/Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients.pdf | |
dc.identifier.doi | 10.1126/scitranslmed.3010825 | |
dc.identifier.doi | https://dx.doi.org/10.7302/21961 | |
dc.identifier.source | Science Translational Medicine | |
dc.description.version | Published version | |
dc.date.updated | 2024-01-09T17:06:20Z | |
dc.identifier.orcid | 0000-0002-2313-8542 | |
dc.identifier.orcid | 0000-0002-5156-9542 | |
dc.description.filedescription | Description of Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients.pdf : Published version | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 285 | |
dc.identifier.startpage | 285ra64 | |
dc.identifier.name-orcid | Morrison, RJ; 0000-0002-2313-8542 | |
dc.identifier.name-orcid | Hollister, SJ | |
dc.identifier.name-orcid | Niedner, MF | |
dc.identifier.name-orcid | Mahani, MG | |
dc.identifier.name-orcid | Park, AH | |
dc.identifier.name-orcid | Mehta, DK | |
dc.identifier.name-orcid | Ohye, RG | |
dc.identifier.name-orcid | Green, GE; 0000-0002-5156-9542 | |
dc.working.doi | 10.7302/21961 | en |
dc.owningcollname | Otolaryngology, Department of |
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