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The role of glycosidically bound mannose in the assimilation of [beta]-galactosidase by generalized gangliosidosis fibroblasts

dc.contributor.authorHieber, Virginia C.en_US
dc.contributor.authorDistler, Jack J.en_US
dc.contributor.authorMyerowitz, Rachelen_US
dc.contributor.authorSchmickel, Roy D.en_US
dc.contributor.authorJourdian, George W.en_US
dc.date.accessioned2006-04-07T16:24:17Z
dc.date.available2006-04-07T16:24:17Z
dc.date.issued1976-12-06en_US
dc.identifier.citationHieber, Virginia, Distler, Jack, Myerowitz, Rachel, Schmickel, Roy D., Jourdian, George W. (1976/12/06)."The role of glycosidically bound mannose in the assimilation of [beta]-galactosidase by generalized gangliosidosis fibroblasts." Biochemical and Biophysical Research Communications 73(3): 710-717. <http://hdl.handle.net/2027.42/21625>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DYN48C-18V/2/4b770f3aad1cafe04e6d1af3d55d8118en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/21625
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=827294&dopt=citationen_US
dc.description.abstractBovine testicular [beta]-galactosidase is rapidly assimilated by generalized gangliosidosis skin fibroblasts. The enzyme contains equimolar amounts of mannose and glucosamine and strongly binds to concanavalin A-Sepharose. Pretreatment of [beta]-galactosidase with a mannosidase preparation from reduced the rate of assimilation of the enzyme 97%. These data indicate that mannosyl residues play a role in assimilation of the enzyme. This conclusion is supported by observed inhibition of [beta]-galactosidase assimilation by mannose, methyl [alpha]- and [beta]-mannopyranosides, and mannose-containing testicular glycoproteins.en_US
dc.format.extent502696 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe role of glycosidically bound mannose in the assimilation of [beta]-galactosidase by generalized gangliosidosis fibroblastsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan, Ann Arbor, Michigan 48109, USA; The Rackham Arthritis Research Unit The University of Michigan, Ann Arbor, Michigan 48109, USA ; Department of Pediatrics The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan, Ann Arbor, Michigan 48109, USA; The Rackham Arthritis Research Unit The University of Michigan, Ann Arbor, Michigan 48109, USA ; Department of Pediatrics The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan, Ann Arbor, Michigan 48109, USA; The Rackham Arthritis Research Unit The University of Michigan, Ann Arbor, Michigan 48109, USA ; Department of Pediatrics The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan, Ann Arbor, Michigan 48109, USA; The Rackham Arthritis Research Unit The University of Michigan, Ann Arbor, Michigan 48109, USA ; Department of Pediatrics The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Pediatrics The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Biological Chemistry The University of Michigan, Ann Arbor, Michigan 48109, USA; The Rackham Arthritis Research Unit The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid827294en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/21625/1/0000004.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(76)90868-8en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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