Heterogeneity of histidine transport in the Ehrlich cell
dc.contributor.author | Wha Bin Im, | en_US |
dc.contributor.author | Christensen, Halvor N. | en_US |
dc.date.accessioned | 2006-04-07T16:24:42Z | |
dc.date.available | 2006-04-07T16:24:42Z | |
dc.date.issued | 1976-11-11 | en_US |
dc.identifier.citation | Wha Bin Im, , Christensen, Halvor N. (1976/11/11)."Heterogeneity of histidine transport in the Ehrlich cell." Biochimica et Biophysica Acta (BBA) - Biomembranes 455(1): 144-151. <http://hdl.handle.net/2027.42/21638> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1T-47TG727-MV/2/b01ada2adb9722f0b8b37d10bf24a6f7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21638 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11000&dopt=citation | en_US |
dc.description.abstract | We have reexamined the heterogeneity shown by histidine in its uptake by the Ehrlich ascites tumor cell, in the face of a contradiction of our earlier interpretation. We again find the fraction of histidine uptake at neutral pH inhibitable by the model substrate for System A, 2-(methylamino)-isobutyric acid, to be fully dependent on the presence of Na+ or Li+. The small Na+-independent component not attributable to System L can be identified with System Ly+ through its inhibitability by homo-arginine. This component increases as the pH is lowered with an apparent pK'a of 6.1. The simultaneous decrease in the uptake by the neutral systems could be identified, for System L, with the same titration of histidine to its cationic form, but for System A the sharp decrease is identified with the protonation of a structure on the membrane rather than one on the substrate. The action of H+ in the latter case proved approximately non-competitive with Na+ when tested with ordinary substrates. | en_US |
dc.format.extent | 330379 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Heterogeneity of histidine transport in the Ehrlich cell | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann. Arbor, Mich. 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann. Arbor, Mich. 48109, U.S.A. | en_US |
dc.identifier.pmid | 11000 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21638/1/0000019.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2736(76)90159-0 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.