Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey
dc.contributor.author | Carney, John M. | en_US |
dc.contributor.author | Llewellyn, Mark E. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.date.accessioned | 2006-04-07T16:25:01Z | |
dc.date.available | 2006-04-07T16:25:01Z | |
dc.date.issued | 1976-11 | en_US |
dc.identifier.citation | Carney, John M., Llewellyn, Mark E., Woods, James H. (1976/11)."Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey." Pharmacology Biochemistry and Behavior 5(5): 577-582. <http://hdl.handle.net/2027.42/21648> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0N-475J5DG-16D/2/769e3464e88919968442b9e13a6fbae9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21648 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=828270&dopt=citation | en_US |
dc.description.abstract | Rhesus monkeys were trained to respond under a variable interval 2 min schedule for codeine or ethanol injections. Both codeine and ethanol were effective in the initiation of variable-interval responding; responding was maintained over a range of codeine (0.003-1.0 mg/kg/injection) and ethanol doses (32.0-560 mg/kg/injection). Maximum rates of responding were obtained at the 0.01 mg/kg/injection codeine dose (0.14 responses/sec) and at the 180 mg/kg/injection codeine dose (0.19 responses/sec). Rates of responsing were bitonic functions of the reinforcer dose for both codeine and ethanol; maximum rates were obtained at intermediate doses and lower rates occurred at the extremes of the dose range. Both codeine and ethanol showed within-session decreases in responding across the range of reinforcer doses. Codeine-reinforced responding declined in rate within the one-hour session without a similar change in the frequency of drug injection; in contrast, both ethanol-reinforced responding and the frequency of ethanol injections declined within each session across a range of doses. Increasing or decreasing the codeine dose half-way through the one-hour session resulted in increases or decreases in codeine responding compared to controls. These data indicate that the progressive decline in codeine-reinforced responding is not the result of a generalized disruption of responding. | en_US |
dc.format.extent | 492871 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Psychology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Psychology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Psychology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 828270 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21648/1/0000032.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0091-3057(76)90272-0 | en_US |
dc.identifier.source | Pharmacology Biochemistry and Behavior | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.