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| Title: | SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION |
| Authors: | Esler, M.
Randall, Otelio S.
Bennett, J.
Zweifler, Andrew J.
Julius, Stevo
Rydelek, P.
Cohen, Edwin L.
Dequattro, V. |
| Issue Date: | 17-Jul-1976 |
| Publisher: | Elsevier |
| Citation: | Esler, M., Randall, O., Bennett, J., Zweifler, A., Julius, S., Rydelek, P., Cohen, E., Dequattro, V. (1976/07/17)."SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION." The Lancet 308(7977): 115-118. <http://hdl.handle.net/2027.42/21720> |
| Abstract: | Study of general haemodynamics in 15 patients with low-renin essential hypertension showed haemodynamic and pathophysiological heterogeneity. However, there was suppression of sympathetic nervous system function in all low-renin patients, regardless of haemodynamic pattern. Subnormal sympathetic nervous activity was manifested by a low normal mean plasma-noradrenaline concentration at rest, diminished noradrenaline responsiveness to postural stimulation, and a reduced blood-pressure response to the indirectly acting sympathomimetic amine tyramine. It is proposed that the syndrome of low-renin essential hypertension is of diverse aetiology, but with secondary sympathetic nervous system underactivity as a feature common to the various forms. The low plasmarenin activity is probably an expression of defective sympathetic nervous system stimulation of renin release. |
| URI: | http://www.sciencedirect.com/science/article/B6T1B-49MMTD9-T
6/2/a2003c0c09f8787ca86e0ca71e5dea56 |
| DOI: | 10.1016/S0140-6736(76)92844-0 |
| Appears in Collections: | Interdisciplinary and Peer-Reviewed
Internal Medicine, Department of
Cardiovascular Center
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| 0000112.pdf | | 451Kb | Adobe PDF | View/Open |
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