Synthesis and phosphorylation of chromatin-associated proteins in cAMP-induced "differentiated" neuroblastoma cells in culture
dc.contributor.author | Lazo, J. S. | en_US |
dc.contributor.author | Prasad, K. N. | en_US |
dc.contributor.author | Ruddon, Raymond W. | en_US |
dc.date.accessioned | 2006-04-07T16:28:15Z | |
dc.date.available | 2006-04-07T16:28:15Z | |
dc.date.issued | 1976-06 | en_US |
dc.identifier.citation | Lazo, J. S., Prasad, K. N., Ruddon, R. W. (1976/06)."Synthesis and phosphorylation of chromatin-associated proteins in cAMP-induced "differentiated" neuroblastoma cells in culture." Experimental Cell Research 100(1): 41-46. <http://hdl.handle.net/2027.42/21755> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WFC-4DXB5HT-6/2/d8777fbee27a9ab968728ccbc7538ab4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21755 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=179831&dopt=citation | en_US |
dc.description.abstract | Prostaglandin E1 and a cAMP phosphodiesterase inhibitor 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, RO20-1724, were used to induce differentiation in mouse neuroblastoma cells in culture. The incorporation of amino acids and phosphate into nuclear proteins of control and drug-treated cells (1 h and 3 days after treatment) was examined using double radioisotopic techniques. A marked decrease in histone synthesis and H1-histone phosphorylation were observed in `differentiated' neuroblastoma cells after 3 days of prostaglandin E1 and RO20-1724 treatment, but only small differences were noted in the synthesis and phosphorylation of non-histone chromatin associated proteins after 3 days of drug treatment. Minimal changes were observed in the labeling of histone and non-histone nuclear proteins if the cells were treated for 1 h with prostaglandin E1 and RO20-1724. | en_US |
dc.format.extent | 532141 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthesis and phosphorylation of chromatin-associated proteins in cAMP-induced "differentiated" neuroblastoma cells in culture | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Radiology, University of Colorado Medical Center, Denver, CO 80220, USA | en_US |
dc.identifier.pmid | 179831 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21755/1/0000149.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-4827(76)90324-4 | en_US |
dc.identifier.source | Experimental Cell Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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