Studies on the cellular site of action of macrophage RNA-antigen complexes
dc.contributor.author | White, Sandra L. | en_US |
dc.contributor.author | Johnson, Arthur G. | en_US |
dc.date.accessioned | 2006-04-07T16:31:38Z | |
dc.date.available | 2006-04-07T16:31:38Z | |
dc.date.issued | 1976-01 | en_US |
dc.identifier.citation | White, Sandra L., Johnson, Arthur G. (1976/01)."Studies on the cellular site of action of macrophage RNA-antigen complexes." Cellular Immunology 21(1): 56-69. <http://hdl.handle.net/2027.42/21865> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCF-4DKVBX9-D0/2/915e3a82d56a2d98b64a48a95bf24f50 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21865 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=55311&dopt=citation | en_US |
dc.description.abstract | Nonadherent spleen cell populations exposed in vitro to ribonucleic acid-rich preparations from mouse macrophages that had been incubated with human [gamma]-globulin (RNA : HGG) were able to produce specific antibody, as measured by rosette-forming cells, in lethally irradiated (800 R), reconstituted, syngeneic mice. Exposure of the RNA to anti-HGG serum abrogated its ability to initiate antibody synthesis, as did monospecific anti-human [gamma] chain and anti-human [kappa] chain serum. Normal rabbit serum, anti-bovine albumin serum, anti-human [mu] chain or anti-human [lambda] chain serum, when substituted for anti-HGG serum had no effect. Thus, the presence of both [gamma] heavy chains and [kappa] light chains of the antigen in the RNA moiety was indicated. Although both an adherent and a nonadherent cell were required by HGG to stimulate rosetteforming cells in irradiated mice, the need for the adherent cell was eliminated when RNA : HGG was substituted for HGG. In addition, anti-[theta]-treated bone marrow cells exposed to the RNA : HGG were capable of rosette-cell formation, suggesting that RNA attachment converted a T cell-dependent antigen to a T cell-independent antigen. | en_US |
dc.format.extent | 1100788 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Studies on the cellular site of action of macrophage RNA-antigen complexes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationum | Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 55311 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21865/1/0000269.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0008-8749(76)90327-0 | en_US |
dc.identifier.source | Cellular Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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