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Properties of the genome in normal and SV40 transformed WI38 human diploid fibroblasts : I. Composition and metabolism of nonhistone chromosomal proteins

dc.contributor.authorKrause, Margarida O.en_US
dc.contributor.authorKleinsmith, Lewis J.en_US
dc.contributor.authorStein, Gary S.en_US
dc.date.accessioned2006-04-07T16:38:15Z
dc.date.available2006-04-07T16:38:15Z
dc.date.issued1975-04en_US
dc.identifier.citationKrause, M. O., Kleinsmith, L. J., Stein, G. S. (1975/04)."Properties of the genome in normal and SV40 transformed WI38 human diploid fibroblasts : I. Composition and metabolism of nonhistone chromosomal proteins." Experimental Cell Research 92(1): 164-174. <http://hdl.handle.net/2027.42/22082>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WFC-4DYVPKK-8D/2/e413f594c9a532bc04f9645524cdce8aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22082
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=165949&dopt=citationen_US
dc.description.abstractThe composition and metabolism of nonhistone chromosomal proteins associated with the genome of normal and SV40 transformed WI38 human diploid fibroblasts were examined. Evidence is presented which indicates variations in the relative protein content, specific activity and phosphorylation of several defined molecular weight classes of these chromosomal polypeptides. In addition, it is shown that blocking DNA replication with cytosine arabinoside does not inhibit the incorporation of 3H-leucine into nonhistone chromosomal proteins of SV40 transformed cells. The possibility that the nonhistone chromosomal proteins of human diploid fibroblasts transformed by SV40 virus may be involved in the regulation of viral induced alterations in gene expression is discussed.en_US
dc.format.extent788153 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleProperties of the genome in normal and SV40 transformed WI38 human diploid fibroblasts : I. Composition and metabolism of nonhistone chromosomal proteinsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Zoology, University of Michigan, Ann Arbor, Mich. 48104, USAen_US
dc.contributor.affiliationotherDepartment of Biochemistry, University of Florida, Gainesville, Fla 32610, USAen_US
dc.contributor.affiliationotherDepartment of Biochemistry, University of Florida, Gainesville, Fla 32610, USAen_US
dc.identifier.pmid165949en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22082/1/0000506.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-4827(75)90650-3en_US
dc.identifier.sourceExperimental Cell Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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