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Pulmonary O-methyl transferases

dc.contributor.authorLaw, Francis C. P.en_US
dc.contributor.authorDrach, John C.en_US
dc.contributor.authorSinsheimer, Joseph E.en_US
dc.date.accessioned2006-04-07T16:40:11Z
dc.date.available2006-04-07T16:40:11Z
dc.date.issued1975-02-01en_US
dc.identifier.citationLaw, Francis C. P., Drach, John C., Sinsheimer, Joseph E. (1975/02/01)."Pulmonary O-methyl transferases." Biochemical Pharmacology 24(3): 385-390. <http://hdl.handle.net/2027.42/22141>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4P-4754GPH-2BB/2/88e9ba14ce13f1bcff2021e6c3e5148den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22141
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1125045&dopt=citationen_US
dc.description.abstractAn investigation in vitro of pulmonary O-methyl transferases revealed the presence of microsomal phenol-O-methyl transferase and soluble and microsomal catechol-O-methyl transferases in guineapig lung tissue. Both phenol and catechol transferases also were detected in rat and rabbit lung tissue. Substrates of guinea-pig pulmonary phenol-O-methyl transferase included phenols, cresols and xylenols. but not alcohols and amines. Catechol-O-methyl transferases from both subcellular sources were found to have similar pH optima, magnesium ion requirements, Km values, and utilized norepinephrine, isoproterenol and dopamine as substrates, but not metaproterenol and salbutamol. These data for the pulmonary enzymes are similar to published values for liver O-methyl transferases.en_US
dc.format.extent685637 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePulmonary O-methyl transferasesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy and Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Mich. 48104, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy and Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Mich. 48104, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy and Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Mich. 48104, U.S.A.en_US
dc.identifier.pmid1125045en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22141/1/0000570.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-2952(75)90222-1en_US
dc.identifier.sourceBiochemical Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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