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Mutagenicity of aliphatic epoxides
dc.contributor.authorWade, D. R.en_US
dc.contributor.authorAiry, Subhash C.en_US
dc.contributor.authorSinsheimer, Joseph E.en_US
dc.date.accessioned2006-04-07T16:58:07Z
dc.date.available2006-04-07T16:58:07Z
dc.date.issued1978-11en_US
dc.identifier.citationWade, D. R., Airy, S. C., Sinsheimer, J. E. (1978/11)."Mutagenicity of aliphatic epoxides." Mutation Research/Genetic Toxicology 58(2-3): 217-223. <http://hdl.handle.net/2027.42/22496>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B73FB-478FC6M-67/2/cf42586a67e15c081508c2375997079een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22496
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=370573&dopt=citationen_US
dc.description.abstractThe mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1,1-Disubstitution resulted in the complete loss or reduction of mutagenicity. trans-1,2-Disubstituted, and tetrasubstituted oxiranes all lacked mutagenicity, while the cis-1,2-disubstituted oxiranes tested were weakly mutagenic in strain TA100 only. For the monosubstituted compounds the presence of electron-withdrawing substituents increased mutagenicity.en_US
dc.format.extent384246 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMutagenicity of aliphatic epoxidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid370573en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22496/1/0000037.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0165-1218(78)90012-5en_US
dc.identifier.sourceMutation Research/Genetic Toxicologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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