Mutagenicity of alkyl-([omega]-hydroxyalkyl) nitrosamines related to dibutylnitrosamine

Olajos, Eugene J.; Maverakis, Nick H.; Cornish, Herbert H.

1978-01

Citation: Olajos, Eugene J., Maverakis, Nick, Cornish, Herbert H. (1978/01)."Mutagenicity of alkyl-([omega]-hydroxyalkyl) nitrosamines related to dibutylnitrosamine." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 56(3): 219-223. <http://hdl.handle.net/2027.42/22725>

Abstract: Various alkyl-([omega]-hydroxyalkyl) derivatives related to dibutylnitrosamine (DBN) were investigated for mutagenicity in the absence of liver-activation system. Butyl-(4-hydroxybutyl)-, butyl-(3-hydroxypropyl)-, and butyl-(2-hydroxyethyl)-nitrosamines were so tested and found to be mutagenic for TA 1535 strain of Salmonella typhimurium. In all cases, a simple dose-response relationship was observed. Furthermore, no significant (p S. typhimurium by the higher dialkylnitrosamines is partially due to the formation of [omega]-hydroxylated derivatives in addition to the major mutagenic metabolite derived from [alpha]-carbon dealkylation.

DOIs: http://dx.doi.org/10.1016/0027-5107(78)90188-4

PMID: 342939

URI: http://www.sciencedirect.com/science/article/B6T2C-48HRWFN-13/2/08f2ae19810030a0fe8df31279e7dbf4
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=342939&dopt=citation

Handle: http://hdl.handle.net/2027.42/22725

Show full item record