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Locating corticospinal neurons by retrograde axonal transport of horseradish peroxidase

dc.contributor.authorHicks, Samuel P.en_US
dc.contributor.authorD'Amato, Constance J.en_US
dc.date.accessioned2006-04-07T17:09:30Z
dc.date.available2006-04-07T17:09:30Z
dc.date.issued1977-08en_US
dc.identifier.citationHicks, Samuel P., D'Amato, Constance J. (1977/08)."Locating corticospinal neurons by retrograde axonal transport of horseradish peroxidase." Experimental Neurology 56(2): 410-420. <http://hdl.handle.net/2027.42/22865>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WFG-4C8H7GM-84/2/231ace4b8eaf79199ce3c714f12cc310en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22865
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=885197&dopt=citationen_US
dc.description.abstractDifferent views of the location and organization of corticospinal (CS) neurons in the rat have resulted from fiber degeneration studies, electrophysiologically derived somatotopic maps, studies of CS axonal branching, and functional alterations after ablation of parts of the motor-sensory cortex. To locate more precisely CS neurons that projected to different levels of the spinal cord, and to determine whether or not they were arranged somatotopically, we labeled them with horseradish peroxidase (HRP) from their cut spinal axons. These labeled neurons were arranged in a major caudal band about 4.5 mm long and 3 mm wide corresponding principally to areas 3, 4, and 6, and a minor rostral band in the anterior part of area 10. The caudal band also corresponded to electrophysiologically derived somatotopic hindlimb and forelimb motor areas. The most significant finding was that CS neurons labeled from the lumbar spinal cord and from cervical levels were intermixed generally throughout the caudal band, showing virtually no somatotopic anatomic arrangement. The rostral band, which corresponded to mouth parts in somatotopic maps, was an unexpected finding. Calculations based on estimates of the numbers of CS axons at different cord levels indicated that about 10,000 CS neurons in each cortex projected as far as the rostral cervical cord, and about 2000 continued as far as lumbar levels. The HRP method as used was capable of labeling a majority of the calculated numbers of CS neurons, but showed a large variance in the total numbers of neurons labeled. The distributions of the neurons within the domains of the bands was consistent regardless of the numbers labeled.en_US
dc.format.extent864493 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLocating corticospinal neurons by retrograde axonal transport of horseradish peroxidaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid885197en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22865/1/0000427.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-4886(77)90357-0en_US
dc.identifier.sourceExperimental Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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