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Inhibition of rat mixed lymphocyte cultures by suppressor macrophages

dc.contributor.authorOehler, J. Ronalden_US
dc.contributor.authorHerberman, Ronald B.en_US
dc.contributor.authorCampbell, Jr. , Darrell A.en_US
dc.contributor.authorDjeu, Julie Y.en_US
dc.date.accessioned2006-04-07T17:12:28Z
dc.date.available2006-04-07T17:12:28Z
dc.date.issued1977-03-15en_US
dc.identifier.citationOehler, J. Ronald, Herberman, Ronald B., Campbell, Jr., Darrell A., Djeu, Julie Y. (1977/03/15)."Inhibition of rat mixed lymphocyte cultures by suppressor macrophages." Cellular Immunology 29(2): 238-250. <http://hdl.handle.net/2027.42/22959>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WCF-4F8KJSB-6Y/2/4fc0a894a18cfaa6cbae264a8d909ae5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22959
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=140766&dopt=citationen_US
dc.description.abstractNormal rat spleens contain suppressor cells which can inhibit proliferative and cytotoxic responses of lymphocytes to alloantigens in vitro. The suppressor cells are adherent, phagocytic, resistant to treatment with ATS and C, radioresistant, resistant to treatment with mitomycin C, apparently absent from the thymus, and found in very high concentrations in peritoneal exudates. These characteristics indicate that the suppressor cell is a macrophages and not a T cell. When suppressor cells were removed from spleen cell suspensions, strong in vitro proliferative and cytotoxic responses to alloantigens could consistently be observed.en_US
dc.format.extent887224 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInhibition of rat mixed lymphocyte cultures by suppressor macrophagesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Immunodiagnosis, National Cancer Institute, Bethesda, Maryland 20014, U.S.A.; Department of General Surgery, University of Michigan Hospital, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of General Surgery, University of Michigan Hospital, Ann Arbor, Michigan 48104, U.S.A.; Laboratory of Immunodiagnosis, National Cancer Institute, Bethesda, Maryland 20014, U.S.A.en_US
dc.contributor.affiliationotherLaboratory of Immunodiagnosis, National Cancer Institute, Bethesda, Maryland 20014, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Immunology, Litton Bionetics, Inc., 5516 Nicholson Lane, Kensington, Maryland 20795, U.S.A.en_US
dc.identifier.pmid140766en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22959/1/0000526.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0008-8749(77)90319-7en_US
dc.identifier.sourceCellular Immunologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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