Show simple item record

Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B

dc.contributor.authorRao, K. Murali Krishnaen_US
dc.contributor.authorSchwartz, Stanley A.en_US
dc.date.accessioned2006-04-07T17:22:59Z
dc.date.available2006-04-07T17:22:59Z
dc.date.issued1980-08en_US
dc.identifier.citationRao, K. Murali Krishna, Schwartz, Stanley A. (1980/08)."Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B." Clinical Immunology and Immunopathology 16(4): 463-473. <http://hdl.handle.net/2027.42/23189>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WCK-4BJW1VV-NR/2/bf7d628b9fdbf7f886cabd6df1e00101en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23189
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6773708&dopt=citationen_US
dc.description.abstractWe have previously reported that zinc affects the mitogenic process in an age-dependent fashion when added to lectin-stimulated lymphocytes. The present studies demonstrate an additional selective effect of zinc when added to Con A-activated lymphocytes plus pharmacologic agents known to affect the cytoskeleton or the permeability of the plasma membrane. Specifically, addition of zinc did not modulate the dose-dependent activities of Ca2+ ionophore A23187, nigericin, or colchicine demonstrating that the immunologic effects of zinc do not involve modification of Ca2+ or K+ fluxes, or microtubule formation. By contrast, a consistent and reproducible shift in the cytochalasin B dose-response curve of lymphocytes stimulated by Con A was observed when zinc was added. These data indicate that the effect of zinc on immune functions may be operating through cytochalasin B-sensitive subcellular structures, most likely microfilaments.en_US
dc.format.extent634835 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleZinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin Ben_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Pediatrics, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid6773708en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23189/1/0000116.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0090-1229(80)90188-9en_US
dc.identifier.sourceClinical Immunology and Immunopathologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.