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Long-term studies of hemoglobin-oxygen affinity in hypoxemic dogs with a right-to-left cardiac shunt

dc.contributor.authorLitwin, S. Berten_US
dc.contributor.authorRosenthal, Amnonen_US
dc.contributor.authorSkogen, William F.en_US
dc.contributor.authorLaver, Myron B.en_US
dc.date.accessioned2006-04-07T17:28:40Z
dc.date.available2006-04-07T17:28:40Z
dc.date.issued1980-02en_US
dc.identifier.citationLitwin, S. Bert, Rosenthal, Amnon, Skogen, William F., Laver, Myron B. (1980/02)."Long-term studies of hemoglobin-oxygen affinity in hypoxemic dogs with a right-to-left cardiac shunt." Journal of Surgical Research 28(2): 118-123. <http://hdl.handle.net/2027.42/23370>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WM6-4CKG0NR-4/2/579f973f541b92500c51b02edfcc3673en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23370
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7359912&dopt=citationen_US
dc.description.abstractLong-standing hypoxemia was surgically created in dogs by inserting an aortic homograft between the inferior vena cava and right atrium. Ligation of the caval--atrial junction resulted in a right-to-left cardiac shunt. Arterial p O2 fell immediately and P50 increased within 20 min. The 2,3-diphosphoglycerate concentration rose in 4 hr following surgery, while hemoglobin concentration increased within 7 days. Alterations in hemoglobin--oxygen affinity can occur rapidly and may be beneficial compensatory responses to acute and chronic hypoxemia caused by a right-to-left cardiac shunt.en_US
dc.format.extent410621 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLong-term studies of hemoglobin-oxygen affinity in hypoxemic dogs with a right-to-left cardiac shunten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumThe Department of Pediatrics of the University of Michigan School of Medicine and The Department of Cardiology, The Children's Hospital, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationotherThe Department of Cardiothoracic Surgery and The Division of Surgery of the Medical College of Wisconsin, The Milwaukee Children's Hospital, Milwaukee, Wisconsin 53233, USAen_US
dc.contributor.affiliationotherThe Department of Cardiothoracic Surgery and The Division of Surgery of the Medical College of Wisconsin, The Milwaukee Children's Hospital, Milwaukee, Wisconsin 53233, USAen_US
dc.contributor.affiliationotherThe Anesthesia Laboratories of the Harvard Medical School, The Massachusetts General Hospital, Boston, Massachusetts 02114, USAen_US
dc.identifier.pmid7359912en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23370/1/0000314.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-4804(80)90154-7en_US
dc.identifier.sourceJournal of Surgical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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