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Cysteine as a system-specific substrate for transport system in rat hepatocytes

dc.contributor.authorKilberg, Michael S.en_US
dc.contributor.authorChristensen, Halvor N.en_US
dc.contributor.authorHandlogten, Mary E.en_US
dc.date.accessioned2006-04-07T17:34:48Z
dc.date.available2006-04-07T17:34:48Z
dc.date.issued1979-05-28en_US
dc.identifier.citationKilberg, Michael S., Christensen, Halvor N., Handlogten, Mary E. (1979/05/28)."Cysteine as a system-specific substrate for transport system in rat hepatocytes." Biochemical and Biophysical Research Communications 88(2): 744-751. <http://hdl.handle.net/2027.42/23564>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4F03B28-10W/2/dfc1702bda53bd6e62e51881b61606bcen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23564
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=465067&dopt=citationen_US
dc.description.abstractThe rapid transport of -cysteine into isolated rat hepatocytes escapes detectable inhibition by 2-(methylamino)-isobutyric acid at levels up to 50 mM. The system transporting cysteine instead is convincingly similar to the system described for the Ehrlich cell in structural and steric specificity and in pH sensitivity. The Na+-dependent uptake of 2-aminoisobutyric acid is almost evenly divided between Systems and , showing better accommodation of its two [alpha]-methyl groups by than in the Ehrlich cell. The hepatocyte system tolerates Li+-for-Na+ substitution better than does System , although the tolerance depends on amino acid structure. Adaptive regulation and insulin and glucagon stimulation were not seen under conditions producing these effects for System .en_US
dc.format.extent435785 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCysteine as a system-specific substrate for transport system in rat hepatocytesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry Medical School The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry Medical School The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry Medical School The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid465067en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23564/1/0000524.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(79)92110-7en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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