Oxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenase
dc.contributor.author | Osimitz, T. G. | en_US |
dc.contributor.author | Kulkarni, Arun P. | en_US |
dc.date.accessioned | 2006-04-07T17:44:59Z | |
dc.date.available | 2006-04-07T17:44:59Z | |
dc.date.issued | 1982-12-31 | en_US |
dc.identifier.citation | Osimitz, T. G., Kulkarni, A. P. (1982/12/31)."Oxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenase." Biochemical and Biophysical Research Communications 109(4): 1164-1171. <http://hdl.handle.net/2027.42/23765> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DYN48C-275/2/369e280bab5150fe076c4caaa6ee6d8e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23765 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7168761&dopt=citation | en_US |
dc.description.abstract | Pregnancy related changes in oxidative metabolism of model substrates were examined in CD1 mice. As compared to nonpregnant females, a significant decrease in the hepatic microsomal aminopyrine-but not in dimethylaniline-N-demethylase activity was observed in pregnant mice. The rates of microsomal flavin-containing monooxygenase-catalyzed N-oxidation of dimethylaniline remained relatively unchanged during pregnancy in the liver, lung, kidney, and uterus. In contrast to this, N-oxidase activity of placental microsomes was increased nearly 5-fold when measured at day 12 and 18 of gestation. | en_US |
dc.format.extent | 454885 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Oxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenase | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Toxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Toxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7168761 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23765/1/0000001.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(82)91899-X | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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