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Dynorphin (1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effects

dc.contributor.authorWalker, J. Michaelen_US
dc.contributor.authorMoises, Hylan C.en_US
dc.contributor.authorCoy, David H.en_US
dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T17:47:20Z
dc.date.available2006-04-07T17:47:20Z
dc.date.issued2006-04-07T17:47:20Z
dc.identifier.citationWalker, J. Michael, Moises, Hylan C., Coy, David H., Young, Elizabeth A., Watson, Stanley J., Akil, Huda ()."Dynorphin (1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effects." Life Sciences 31(16-17): 1821-1824. <http://hdl.handle.net/2027.42/23835>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-478B4R6-246/2/5e1d9619f390e0b1e02c7022596673a3en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23835
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6130448&dopt=citationen_US
dc.description.abstractDynorphin and an opiate-inactive fragment des-Tyr-dynorphin produced similar effects on EEG, motor function and hippocampal unit firing. Naloxone had no effect on the actions of dynorphin in these systems and dynorphin failed to produce analgesia upon central administration. These results suggest that dynorphin has a pharmacological character that differs significantly from the classic narcotics.en_US
dc.format.extent248748 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDynorphin (1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effectsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, Ann Arbor, Michigan 48109, USA.en_US
dc.identifier.pmid6130448en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23835/1/0000074.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(82)90219-3en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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