Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig
dc.contributor.author | Takada, Akira | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.date.accessioned | 2006-04-07T17:47:39Z | |
dc.date.available | 2006-04-07T17:47:39Z | |
dc.date.issued | 1982-10 | en_US |
dc.identifier.citation | Takada, Akira, Schacht, Jochen (1982/10)."Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig." Hearing Research 8(2): 179-186. <http://hdl.handle.net/2027.42/23845> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-485GKXP-KN/2/930b6c9ede42fb3dcf9d701e1ce303d9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23845 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7142042&dopt=citation | en_US |
dc.description.abstract | The perilymphatic space of the guinea pig cochlea was perfused with various concentrations of Ca2+, Mg2+ and gentamicin. Cochlear microphonic potentials (CM) were essentially stable when solutions contained 1 mM Ca2+ plus 2 mM Mg2+, 1 mM Ca2+ and no Mg2+ or when both Ca2+ and Mg2+ were omitted. In the absence of Ca2+, the presence of 2 mM Mg2+ or 1 mM EGTA markedly decreased CM.Addition of 3 mM gentamicin lowered CM, the magnitude of the effect depending on the concentration of Ca2+ present. Ten mM Ca2+ eliminated the action of the drug. In the absence of Ca2+, the effects of Mg2+ and gentamicin were additive.When the application of gentamicin was followed by perfusion with drug-free medium, suppression of CM by 3 mM drug could be reversed with 10 mM Ca2+ but not with 1 mM Ca2+. Loss of CM was irreversible when administration of 10 mM Ca2+ was delayed or when the drug concentration was increased to 10 mM.The results are consistent with our previous hypothesis of a biphasic mechanism of aminoglycoside toxicity: an initial action competitive with calcium ions and reversible and a second step, non-competitive and irreversible. | en_US |
dc.format.extent | 641486 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7142042 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23845/1/0000084.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(82)90073-9 | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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