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Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes

dc.contributor.authorDelaforge, Marcelen_US
dc.contributor.authorKoop, Dennis R.en_US
dc.contributor.authorCoon, Minor J.en_US
dc.date.accessioned2006-04-07T17:48:15Z
dc.date.available2006-04-07T17:48:15Z
dc.date.issued1982-09-16en_US
dc.identifier.citationDelaforge, Marcel, Koop, Dennis R., Coon, Minor J. (1982/09/16)."Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes." Biochemical and Biophysical Research Communications 108(1): 59-65. <http://hdl.handle.net/2027.42/23864>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DYVHVW-1XT/2/40f0602b781ba261c32d3fa7f05f539ben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23864
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6816232&dopt=citationen_US
dc.description.abstractIsosafrole serves as an excellent inducing agent in rabbits for P-450LM4, the same isozyme as that which is induced by 3-methylcholanthrene and 5,6-benzoflavone. Since the isosafrole adduct formed with isozyme 4 is unstable, the uncomplexed cytochrome may be purified in very good yield (over 30%, based on total P-450) from liver microsomes of animals given this agent. Isosafrole forms adducts with both isozyme 2 (the phenobarbital-inducible form of P-450) and isozyme 4 in the reconstituted system containing NADPH-cytochrome P-450 reductase, phosphatidylcholine, and NADPH under aerobic conditions, but with the latter cytochrome the reaction has a lower Km and maximal rate.en_US
dc.format.extent439873 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleRole of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid6816232en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23864/1/0000103.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(82)91831-9en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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