Location and structure of the var1 gene on yeast mitochondrial DNA: Nucleotide sequence of the 40.0 allele
dc.contributor.author | Hudspeth, Michael E. S. | en_US |
dc.contributor.author | Ainley, W. Michael | en_US |
dc.contributor.author | Shumard, Deborah S. | en_US |
dc.contributor.author | Butow, Ronald A. | en_US |
dc.contributor.author | Grossman, Lawrence I. | en_US |
dc.date.accessioned | 2006-04-07T17:48:56Z | |
dc.date.available | 2006-04-07T17:48:56Z | |
dc.date.issued | 1982-09 | en_US |
dc.identifier.citation | Hudspeth, Michael E. S., Ainley, W. Michael, Shumard, Deborah S., Butow, Ronald A., Grossman, Lawrence I. (1982/09)."Location and structure of the var1 gene on yeast mitochondrial DNA: Nucleotide sequence of the 40.0 allele." Cell 30(2): 617-626. <http://hdl.handle.net/2027.42/23885> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WSN-4C8FYKG-11/2/c09156f97721253ed55e2f79d58f8c9d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23885 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6754087&dopt=citation | en_US |
dc.description.abstract | Alleles of the var1 locus on yeast mitochondrial DNA specify the size of var1 ribosomal protein. We report the nucleotide sequence of a var1 allele that determines the smallest var1 protein. It contains an open reading frame of 396 codons, which we identify as the structural gene for var1 protein. The var1 protein specified by this allele has an amino acid composition in close agreement with that predicted by the DNA sequence. The var1 coding region is highly unusual: it is 89.6% AT and contains a 46 bp GC-rich palindromic cluster that accounts for 38% of the total GC residues. Our results strongly suggest that like mammalian mitochondria but unlike those from Neurospora, yeast mitochondria use AUA as a methionine codon. Comparison with the sequence of a var1 allele specifying a larger protein suggests that some size polymorphism of var1 protein results from in-frame insertions of a variable number of AAT (Asn) codons. | en_US |
dc.format.extent | 1749534 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Location and structure of the var1 gene on yeast mitochondrial DNA: Nucleotide sequence of the 40.0 allele | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cellular and Molecular Biology Division of Biological Sciences The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Cellular and Molecular Biology Division of Biological Sciences The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Cellular and Molecular Biology Division of Biological Sciences The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry Division of Molecular Biology The University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry Division of Molecular Biology The University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA | en_US |
dc.identifier.pmid | 6754087 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23885/1/0000124.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0092-8674(82)90258-6 | en_US |
dc.identifier.source | Cell | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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