NAD/NADH as a model redox system: Mechanism, mediation, modification by the environment
dc.contributor.author | Elving, Philip Juliber | en_US |
dc.contributor.author | Bresnahan, William T. | en_US |
dc.contributor.author | Moiroux, Jacques | en_US |
dc.contributor.author | Samec, Zdenek | en_US |
dc.date.accessioned | 2006-04-07T17:50:48Z | |
dc.date.available | 2006-04-07T17:50:48Z | |
dc.date.issued | 1982-07 | en_US |
dc.identifier.citation | Elving, Philip J., Bresnahan, William T., Moiroux, Jacques, Samec, Zdenek (1982/07)."NAD/NADH as a model redox system: Mechanism, mediation, modification by the environment." Bioelectrochemistry and Bioenergetics 9(3): 365-378. <http://hdl.handle.net/2027.42/23943> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TF7-458P264-G/2/662ca5d4440b265fa82ea35d4b771dd3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23943 | |
dc.description.abstract | The biologically important redox couple, [beta]-nicotinamide adenine dinucleotide/1,4,[beta]-dihydronicotinamide adenine dinucleotide, provides a grossly reversible prototype system for an overall electrode reaction consisting of two successive one-electron (1 e-) transfer steps coupled with (a) dimerization of an intermediate free radical product, (b) protonation-deprotonation of an intermediate product, (c) other chemical reactions, (d) adsorption of reactant, intermediate and product species, and (e) mediation by electrode surface species. Cathodic reduction of NAD+ proceeds through two 1 e- steps well separated in potential; protonation of the free radical produced on the first step occurs prior to the second electron-transfer; a first-order chemical reaction coupled to the latter may involve rearrangement of an initial dihydro product to 1,4-NADH (and some 1,6-NADH). In the apparently single stage 2 e- anodic oxidation of NADH, the initial step is an irreversible heterogeneous electron transfer, which proceeds to at least some extent through mediator redox systems located close to the electrode surface; the resulting cation radical, NADH+[middle dot], loses a proton (first order reaction) to form a neutral radical, NAD[middle dot], which may participate in a second heterogeneous electron transfer (ECE mechanism) or may react with NADH+[middle dot] (disproportionation mechanism DISP 1 or half-regeneration mechanism) to yield NAD+. | en_US |
dc.format.extent | 830651 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | NAD/NADH as a model redox system: Mechanism, mediation, modification by the environment | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23943/1/0000190.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0302-4598(82)80026-3 | en_US |
dc.identifier.source | Bioelectrochemistry and Bioenergetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.