Isomerization of trans-diethylstilbestrol to pseudo-diethylstilbestrol
dc.contributor.author | Airy, Subhash C. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-07T18:00:38Z | |
dc.date.available | 2006-04-07T18:00:38Z | |
dc.date.issued | 1981-11 | en_US |
dc.identifier.citation | Airy, Subhash C., Sinsheimer, Joseph E. (1981/11)."Isomerization of trans-diethylstilbestrol to pseudo-diethylstilbestrol." Steroids 38(5): 593-603. <http://hdl.handle.net/2027.42/24220> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TC9-47MJS36-1X/2/67d8b5efb4b5e66f83a9bfe0c99a5c0d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24220 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7324087&dopt=citation | en_US |
dc.description.abstract | This study reports the formation and isolation of a diethyl-stilbestrol-dimethylsulfoxide (DES-DMSO) adjunct and Z-3, 4-di(p-hydroxyphenyl)-2-hexene ([psi]-DES) from -DES. The presence of [psi]-DES was indicated by NMR and mass spectrometry and confirmed by direct comparison to a reference sample. High resolution NMR(360 MHz) along with the comparison of the chemical shift values of methine and methyl protons attached to carbon-carbon double bonds in Z and E isomers of 3-substituted-2-pentenes and dienestrol derivatives were used in postulating the Z-stereochemistry for [psi]-DES. A NMR additive increment method was useful for the comparison of the chemical shift values of methine protons in [psi]-DES and other literature compounds. Nuclear Overhauser Enhancement (NOE) confirmed the Z-stereochemistry of [psi]-DES. | en_US |
dc.format.extent | 465546 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Isomerization of trans-diethylstilbestrol to pseudo-diethylstilbestrol | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7324087 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24220/1/0000479.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0039-128X(81)90057-X | en_US |
dc.identifier.source | Steroids | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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