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Axonal transport maintains taste responses

dc.contributor.authorOakley, Bruceen_US
dc.contributor.authorChu, Joyce S.en_US
dc.contributor.authorJones, Lee B.en_US
dc.date.accessioned2006-04-07T18:01:52Z
dc.date.available2006-04-07T18:01:52Z
dc.date.issued1981-09-28en_US
dc.identifier.citationOakley, Bruce, Chu, Joyce S., Jones, Lee B. (1981/09/28)."Axonal transport maintains taste responses." Brain Research 221(2): 289-298. <http://hdl.handle.net/2027.42/24253>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-4840J24-20/2/f93241989a97278c0abfbce3c0464c98en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24253
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6169394&dopt=citationen_US
dc.description.abstractTransection of the gerbil's IXth nerve causes gustatory action potentials to decline in 1-6 h; the rate of decline is a linear function of the length of the nerve stump remaining attached to the tongue18. To test the implication that taste discharge mechanisms depend upon axonal transport in the IXth nerve, we injected 40 nl of [3H]leucine into the petrosal ganglion of one IXth nerve of the gerbil, Meriones unguiculatus. Subsequent liquid scintillation counting of the petrosal ganglion, IXth nerve segments, and representative areas of the tongue indicated that labeled materials were transported down the IXth nerve primarily to the vallate and ipsilateral foliate taste papillae of the tongue. A significant impairment of axonal transport and a substantial decline in summated IXth nerve taste responses occurred within 2-3 h a after colchicine was applied to the IXth nerve trunk between the tongue and the petrosal ganglion. Similarly, cooling the IXth nerve with a 3-10 [deg]C thermocouple junction or metal probe impaired axonal transport and caused a taste response decline. Since impulse mechanisms of the nerve trunk continued to function distal to these sites of treatment, we concluded that the maintenance of taste discharges at the level of the taste bud depends upon unimpeded axonal transport.en_US
dc.format.extent625470 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAxonal transport maintains taste responsesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Biological Sciences, Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Mich. 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Biological Sciences, Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Mich. 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Biological Sciences, Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Mich. 48109, U.S.A.en_US
dc.identifier.pmid6169394en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24253/1/0000516.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(81)90778-2en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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