Metabolic basis for disorders of purine nucleotide degradation

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Title:	Metabolic basis for disorders of purine nucleotide degradation
Authors:	Fox, Irving H.
Issue Date:	Jun-1981
Publisher:	Elsevier
Citation:	Fox, Irving H. (1981/06)."Metabolic basis for disorders of purine nucleotide degradation." Metabolism 30(6): 616-634. <http://hdl.handle.net/2027.42/24368>
Abstract:	Purine nucleotide degradation refers to a regulated series of reactions by which human purine ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two major types of disorders occur in this pathway. A block of degradation occurs with syndromes involving immune deficiency, myopathy or renal calculi. Increased degradation of nucleotides occurs with syndromes characterized by hyperuricemia and gout, renal calculi, anemia or acute hypoxia. Management of disorders of purine nucleotide degradation is dependent upon modifying the specific molecular pathology underlying each disease state.
URI:	http://www.sciencedirect.com/science/article/B6WN4-4C2S7YX-6 F/2/8efa80567af4ff49b7ba70b0c602507c http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db =pubmed&list_uids=6262603&dopt=citation
DOI:	10.1016/0026-0495(81)90142-6
PMID:	6262603
Appears in Collections:	Interdisciplinary and Peer-Reviewed

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