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Induction of analgesia by central administration of ORG 2766, an analog of ACTH4-9

dc.contributor.authorWalker, J. Michaelen_US
dc.contributor.authorBerntson, Gary G.en_US
dc.contributor.authorSandman, Curt A.en_US
dc.contributor.authorKastin, Abba J.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T18:10:03Z
dc.date.available2006-04-07T18:10:03Z
dc.date.issued1981-01-05en_US
dc.identifier.citationWalker, J. Michael, Berntson, Gary G., Sandman, Curt A., Kastin, Abba J., Akil, Huda (1981/01/05)."Induction of analgesia by central administration of ORG 2766, an analog of ACTH4-9." European Journal of Pharmacology 69(1): 71-79. <http://hdl.handle.net/2027.42/24482>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T1J-4772VSB-20H/2/722364c86596883f6ef91ed5cfd96068en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24482
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6258942&dopt=citationen_US
dc.description.abstractDose-dependent analgesia was produced by microinjection of ORG 2766 into the periaqueductal gray (PAG). This analgesia was found to be potent and long-lasting and occurred at doses which were equimolar to those necessary for morphine analgesia. The same doses failed to produce analgesia by the cerebroventricular route, suggesting that the PAG was the site of action of this effect. Naloxone failed to reduce the analgesia and morphine tolerance did not diminish the effect significantly. Additionally, ORG 2766 at concentrations up to 10 [mu]M failed to inhibit binding of [3H]naloxone to brain opiate receptors in vitro. These results suggest a non-opiate mechanism of action and are discussed in terms of a proposed [alpha]-MSH or ACTH receptor.en_US
dc.format.extent656022 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInduction of analgesia by central administration of ORG 2766, an analog of ACTH4-9en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, Ohio State University, Columbus, Ohio 43210, USA; Tulane University School of Medicine and Veterans Administration Hospital, New Orleans, Lousiana 70112, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A.en_US
dc.contributor.affiliationumTulane University School of Medicine and Veterans Administration Hospital, New Orleans, Lousiana 70112, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A.; Department of Psychology, Ohio State University, Columbus, Ohio 43210, USAen_US
dc.contributor.affiliationumTulane University School of Medicine and Veterans Administration Hospital, New Orleans, Lousiana 70112, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A.; Department of Psychology, Ohio State University, Columbus, Ohio 43210, USAen_US
dc.contributor.affiliationumTulane University School of Medicine and Veterans Administration Hospital, New Orleans, Lousiana 70112, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A.; Department of Psychology, Ohio State University, Columbus, Ohio 43210, USAen_US
dc.contributor.affiliationumTulane University School of Medicine and Veterans Administration Hospital, New Orleans, Lousiana 70112, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A.; Department of Psychology, Ohio State University, Columbus, Ohio 43210, USAen_US
dc.identifier.pmid6258942en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24482/1/0000757.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-2999(81)90603-8en_US
dc.identifier.sourceEuropean Journal of Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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