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Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

dc.contributor.authorCarter, Nicholas D.en_US
dc.contributor.authorChegwidden, W. Richarden_US
dc.contributor.authorHewett-Emmett, Daviden_US
dc.contributor.authorJeffery, S.en_US
dc.contributor.authorShiels, A.en_US
dc.contributor.authorTashian, Richard E.en_US
dc.date.accessioned2006-04-07T18:32:10Z
dc.date.available2006-04-07T18:32:10Z
dc.date.issued1984-01-09en_US
dc.identifier.citationCarter, N. D., Chegwidden, W. R., Hewett-Emmett, D., Jeffery, S., Shiels, A., Tashian, R. E. (1984/01/09)."Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate." FEBS Letters 165(2): 197-200. <http://hdl.handle.net/2027.42/24933>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T36-44DT20D-HM/2/eee3a084163dc1c792b777d97def1a8cen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/24933
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6420187&dopt=citationen_US
dc.description.abstractCarbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.en_US
dc.format.extent441677 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNovel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphateen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Sciences, Sheffield City Polytechnic, Sheffield S1 1WB England.en_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Child Health, St. George's Hospital Medical School, London SW17 ORE, Englanden_US
dc.contributor.affiliationotherDepartment of Child Health, St. George's Hospital Medical School, London SW17 ORE, Englanden_US
dc.contributor.affiliationotherDepartment of Child Health, St. George's Hospital Medical School, London SW17 ORE, Englanden_US
dc.identifier.pmid6420187en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/24933/1/0000360.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-5793(84)80168-4en_US
dc.identifier.sourceFEBS Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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