The effect of dobutamine on exercise performance in patients with symptomatic ischemic heart disease
dc.contributor.author | Rabinovitch, Mark A. | en_US |
dc.contributor.author | Kalff, Victor | en_US |
dc.contributor.author | Chan, William | en_US |
dc.contributor.author | Schork, Anthony | en_US |
dc.contributor.author | Gross, Milton D. | en_US |
dc.contributor.author | Vogel, Robert A. | en_US |
dc.contributor.author | Thrall, James H. | en_US |
dc.contributor.author | Pitt, Bertram | en_US |
dc.date.accessioned | 2006-04-07T18:33:02Z | |
dc.date.available | 2006-04-07T18:33:02Z | |
dc.date.issued | 1984-01 | en_US |
dc.identifier.citation | Rabinovitch, Mark A., Kalff, Victor, Chan, William, Schork, Anthony, Gross, Milton D., Vogel, Robert A., Thrall, James H., Pitt, Bertram (1984/01)."The effect of dobutamine on exercise performance in patients with symptomatic ischemic heart disease." American Heart Journal 107(1): 81-85. <http://hdl.handle.net/2027.42/24958> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BTH8PR-85/2/abccbeee5b28fc14f6ef635553bc8483 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24958 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6691244&dopt=citation | en_US |
dc.description.abstract | The effect of dobutamine on exercise performance was assessed in 20 patients with ischemic heart disease (CAD) and a positive stress test. These patients had a wide range of resting left ventricular ejection fraction (range 22% to 69%, mean 42%). Each patient entered a double-blind crossover study in which two identical exercise radionuclide ventriculograms were performed in patients on dobutamine, 5 [mu]g/kg/min intravenously, or placebo. Dobutamine increased resting left ventricular ejection fraction. Although ejection fraction fell with dobutamine during submaximal exercise, it remained higher than with placebo. At peak exercise, ejection fraction fell to the same level on dobutamine as with placebo. Dobutamine diminished exercise time and time to ischemia while peak pressure-rate product was unchanged. Four of 20 patients developed complex ventricular premature beats, all while on dobutamine. Although useful when administered to resting patients with acute left ventricular failure, dobutamine's effects may be deleterious in exercising patients with chronic ischemic heart disease. | en_US |
dc.format.extent | 601306 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effect of dobutamine on exercise performance in patients with symptomatic ischemic heart disease | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA;The Veterans Administration Medical Center, Ann Arbor, Mich., USA. | en_US |
dc.identifier.pmid | 6691244 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24958/1/0000385.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(84)90137-6 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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