The rotational behavior model: asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats

Robinson, Terry E.; Becker, Jill B.

1983-03-28

Citation: Robinson, Terry E., Becker, Jill B. (1983/03/28)."The rotational behavior model: asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats." Brain Research 264(1): 127-131. <http://hdl.handle.net/2027.42/25262>

Abstract: A basic assumption of the `rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine (DA) system. However, we report here that if the normally `dominant' striatum is partially depleted of DA the majority of rats turn contraversive when given AMPH, i.e. in the opposite direction predicted by the model.

DOIs: http://dx.doi.org/10.1016/0006-8993(83)91129-0

PMID: 6405975

URI: http://www.sciencedirect.com/science/article/B6SYR-48361RV-14H/2/52e2b302c0769791b4b9ad4a1a148e32
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6405975&dopt=citation

Handle: http://hdl.handle.net/2027.42/25262

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