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NMR chemistry analysis of red blood cell constituents in normal subjects and lithium-treated psychiatric patients

dc.contributor.authorDomino, Edward F.en_US
dc.contributor.authorSharp, Robert R.en_US
dc.contributor.authorLipper, Stevenen_US
dc.contributor.authorBallast, Christian L.en_US
dc.contributor.authorDelidow, Beverlyen_US
dc.contributor.authorBronzo, Michael R.en_US
dc.date.accessioned2006-04-07T18:54:01Z
dc.date.available2006-04-07T18:54:01Z
dc.date.issued1985-12en_US
dc.identifier.citationDomino, Edward F., Sharp, Robert R., Lipper, Steven, Ballast, Christian L., Delidow, Beverly, Bronzo, Michael R. (1985/12)."NMR chemistry analysis of red blood cell constituents in normal subjects and lithium-treated psychiatric patients." Biological Psychiatry 20(12): 1277-1283. <http://hdl.handle.net/2027.42/25491>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4S-482YRV5-R/2/06ed0ef60421e8fd130b00ddad8ac7a4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25491
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4063417&dopt=citationen_US
dc.description.abstractRed blood cells from 18 lithium carbonate-treated patients with bipolar affective disorder and 12 normal volunteers were analyzed using 1H-nuclear magnetic resonance (NMR) spectroscopy. The spectra were analyzed for alanine, adenosine triphosphate (ATP), choline, 2,3-diphosphoglycerol, glucose, glutathione, glycine, and lactate. Significant elevations of choline and lactate were found in the lithium-treated patients compared with normal, unmedicated subjects. The elevation of lactate due to anaerobic metabolism in the red blood cells was further investigated via fluoremetric analysis and appears to be caused by blood standing at room temperature. The observed increases in red blood cell choline are sufficiently high and statistically significant to warrant additional studies on the dramatic effects of lithium on this red cell metabolite, which might be important for an understanding of its mechanism of action in psychiatric disorders.en_US
dc.format.extent398539 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNMR chemistry analysis of red blood cell constituents in normal subjects and lithium-treated psychiatric patientsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology, Chemistry, and Psychiatry, University of Michigan, Ann Arbor, MI, USAen_US
dc.identifier.pmid4063417en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25491/1/0000032.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-3223(85)90112-Xen_US
dc.identifier.sourceBiological Psychiatryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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