Computerized drug therapy: Application of the hand-held microcomputer to dosage regimen design
dc.contributor.author | Brouwer, K. R. | en_US |
dc.contributor.author | Cook, Jack A. | en_US |
dc.contributor.author | Steinke, M. | en_US |
dc.contributor.author | Gwilt, Peter R. | en_US |
dc.date.accessioned | 2006-04-07T19:02:59Z | |
dc.date.available | 2006-04-07T19:02:59Z | |
dc.date.issued | 1985-07 | en_US |
dc.identifier.citation | Brouwer, K. R., Cook, J., Steinke, M., Gwilt, P. R. (1985/07)."Computerized drug therapy: Application of the hand-held microcomputer to dosage regimen design." International Journal of Bio-Medical Computing 17(1): 49-55. <http://hdl.handle.net/2027.42/25624> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B7GH2-4C4WFXP-5/2/29b5c4f3f1b11e4e0871df750b88012f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25624 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3840458&dopt=citation | en_US |
dc.description.abstract | For many drugs estimation of a safe and effective dosage regimen is difficult. Typically these drugs exhibit optimal therapeutic activity when drug concentrations in the blood are maintained within narrow limits and considerable intersubject variability exists in their rate of elimination from the body.Computer programs have been written to estimate the size and frequency of dose administration necessary to achieve therapeutic drug concentrations in the blood. The programs utilize pharmacokinetic equations and information on the individual patient's physiologic (e.g., age, weight, sex) and pathologic (e.g., existence of liver or renal disease) status.The drugs studied were gentamicin, theophylline, digoxin, phenytoin and wafarin. The programs were written using the hand-held TRS 80 Pocket Computer with an 8K memory module. These programs have been in use for 3 years and are currently involved in clinical consults approx. 100 times a month. | en_US |
dc.format.extent | 548986 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Computerized drug therapy: Application of the hand-held microcomputer to dosage regimen design | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | West European Studies | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Humanities | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Kalamazoo, MI, U.S.A. | en_US |
dc.contributor.affiliationother | College of Pharmacy, University of Kentucky, Kalamazoo, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacy, Borgess Hospital, Kalamazoo, MI, U.S.A. | en_US |
dc.contributor.affiliationother | School of Pharmacy, West Virginia University, Morgantown, WV 26506, U.S.A. | en_US |
dc.identifier.pmid | 3840458 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25624/1/0000174.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0020-7101(85)90072-8 | en_US |
dc.identifier.source | International Journal of Bio-Medical Computing | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.