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Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives

dc.contributor.authorFrantz, Stephen W.en_US
dc.contributor.authorVan Den Eeckhout, E.en_US
dc.contributor.authorSinsheimer, Joseph E.en_US
dc.contributor.authorYoshihara, M.en_US
dc.contributor.authorKoreeda, Masatoen_US
dc.date.accessioned2006-04-07T19:04:14Z
dc.date.available2006-04-07T19:04:14Z
dc.date.issued1985-06en_US
dc.identifier.citationFrantz, S. W., van den Eeckhout, E., Sinsheimer, J. E., Yoshihara, M., Koreeda, M. (1985/06)."Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives." Toxicology Letters 25(3): 265-271. <http://hdl.handle.net/2027.42/25651>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCR-477Y2NM-22M/2/709c63009e36e0d21eeb659100f2c6ccen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25651
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4012804&dopt=citationen_US
dc.description.abstract15 Cyclohexane epoxide derivatives were synthesized and compared for direct mutagenicity an bacterial toxicity using Salmonella typhimurium strain TA100 in the liquid suspension and spot-test version of the Ames procedure. While no general correlations could be established for position and stereochemistry of the hydroxylated derivatives, an increase in mutagenicity was noted for the presence of electron-withdrawing groups and unsaturation in conjugation with the oxirane groups.en_US
dc.format.extent435694 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMutagenicity in Salmonella assays of cyclohexane epoxide derivativesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumCollege of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid4012804en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25651/1/0000203.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4274(85)90206-1en_US
dc.identifier.sourceToxicology Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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