View Item 

Show simple item record

Involvement of nigrostriatal dopamine neurons in the contraversive rotational behavior evoked by electrical stimulation of the lateral hypothalamus

dc.contributor.authorCastaneda, Edwarden_US
dc.contributor.authorRobinson, Terry E.en_US
dc.contributor.authorBecker, Jill B.en_US
dc.date.accessioned2006-04-07T19:08:55Z
dc.date.available2006-04-07T19:08:55Z
dc.date.issued1985-02-18en_US
dc.identifier.citationCastaneda, Edward, Robinson, Terry E., Becker, Jill B. (1985/02/18)."Involvement of nigrostriatal dopamine neurons in the contraversive rotational behavior evoked by electrical stimulation of the lateral hypothalamus." Brain Research 327(1-2): 143-151. <http://hdl.handle.net/2027.42/25753>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-484M9T6-1TR/2/ec1f4c085a9089b610a4a212b3f90ddeen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25753
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3921190&dopt=citationen_US
dc.description.abstractThis experiment was conducted to determine if nigrostriatal dopamine (DA) neurons are necessary for the contraversive rotational behavior evoked by electrical stimulation in the lateral hypothalamus. Rats were tested daily for electrical stimulation-induced rotational behavior (ESRB) for 5 days, and then given an injection of 6-hydroxydopamine (6-OHDA) or saline into the ipsilateral substantia nigra. The nearly total depletion of striatal DA (&gt; 96%) completely abolished contraversive ESRB and resulted in the appearance of ipsiversive ESRB. Partial DA depletion (p-tyrosine (40 mg/kg) attenuated contraversive ESRB, while having no effect on control animals, or the ipsiversive turning in animals with &gt; 96% DA depletion. We conclude that the nigrostriatal DA system is necessary for contraversive rotational behavior evoked by lateral hypothalamic stimulation, but that only a small percentage of DA fibers are required to maintain apparently `normal' function--at least as indicated by contraversive ESRB.en_US
dc.format.extent802190 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInvolvement of nigrostriatal dopamine neurons in the contraversive rotational behavior evoked by electrical stimulation of the lateral hypothalamusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPsychology Department and Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron St., Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.contributor.affiliationumPsychology Department and Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron St., Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.contributor.affiliationumPsychology Department and Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron St., Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.identifier.pmid3921190en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25753/1/0000313.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(85)91508-2en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000313.pdf
Size:
783.3KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.