Free radicals in ischemic myocardial injury
dc.contributor.author | Werns, Steven W. | en_US |
dc.contributor.author | Shea, Michael J. | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T19:12:41Z | |
dc.date.available | 2006-04-07T19:12:41Z | |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Werns, Steven W., Shea, Michael J., Lucchesi, Benedict R. (1985)."Free radicals in ischemic myocardial injury." Journal of Free Radicals in Biology & Medicine 1(2): 103-110. <http://hdl.handle.net/2027.42/25835> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73GN-47GGK4H-3/2/9db984159dec30f339da1ec0de29ca7d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25835 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3939137&dopt=citation | en_US |
dc.description.abstract | Myrocardial ischemia causes release of chemotactic factors, migration of neutrophils, peroxidation of lipids, and depletion of free radical scavengers. The invading neutrophils may injure the myrocardial vasculature and sarcolemma by generating oxygen free radicals. Several agents that affect neutrophils or oxygen radicals were evaluated in a canine model of regional myocardial ischemia and reperfusion. Anesthetized dogs underwent occlusion and reperfusion of the left circumflex coronary artery. Infarct zone, area at risk infarction, and total left ventricle were quantified by gravimetric and planimetric analysis. Limitation of infarct size by ibuprofen was associated with marked suppression of leukocyte accumulation within the ischemic myocardium. Neutrophil depletion by antiserum resulted in similar reductions of infarct size and was accompanied by a reduction in leukocyte infiltration. A combination of oxygen radical scaverngers, superoxide dismutase plus catalase, decreased myocardial injury whether infusion began before occlusion or 75 min after occlusion. None of the treatments significantly altered hemodynamic indices of myocardial oxygen demand. Reduction of infarct size by ibuprofen, neutrophil antiserum, and free radical scavengers indicates that neutrophils and oxygen radicals participate in producing the irreversible damage to the myocardium during ischemia and reperfusion. | en_US |
dc.format.extent | 797986 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Free radicals in ischemic myocardial injury | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Cardiology) The University of Michigan Medicine School, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Cardiology) The University of Michigan Medicine School, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology The University of Michigan Medicine School, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.identifier.pmid | 3939137 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25835/1/0000398.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0748-5514(85)90013-3 | en_US |
dc.identifier.source | Journal of Free Radicals in Biology & Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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