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Oxygen radicals in complement and neutrophil-mediated acute lung injury

dc.contributor.authorTill, Gerd O.en_US
dc.contributor.authorWard, Peter A.en_US
dc.date.accessioned2006-04-07T19:13:30Z
dc.date.available2006-04-07T19:13:30Z
dc.date.issued1985en_US
dc.identifier.citationTill, Gerd O., Ward, Peter A. (1985)."Oxygen radicals in complement and neutrophil-mediated acute lung injury." Journal of Free Radicals in Biology &amp; Medicine 1(2): 163-168. <http://hdl.handle.net/2027.42/25857>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B73GN-47GGK4H-C/2/b2ae6263c727e229bbd8750a752c0e27en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25857
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3915302&dopt=citationen_US
dc.description.abstractThe development of experimental acute lung injury following systemic complement activation is closely related to availability of blood neutrophils. Although tissue-destructive neutrophil-derived may play a supportive role in acute pulmonary injury, it appears that oxygen radical constitute the major neutrophil product responsible for acute damage of lung tissues and cells. Intravascular activation of neutrophils by the chemotactic complement peptide C5a is related to the generation os superoxide anion. Dismutation of superoxide to hydrogen peroxide and its iron-mediated conversion to hydroxyl radical appear to constitute in vivo events that ultimately lead to acute lung microvascular injury.en_US
dc.format.extent577860 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleOxygen radicals in complement and neutrophil-mediated acute lung injuryen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109-0010, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109-0010, U.S.A.en_US
dc.identifier.pmid3915302en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25857/1/0000420.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0748-5514(85)90021-2en_US
dc.identifier.sourceJournal of Free Radicals in Biology &amp; Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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