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The role of endorphins and vasopressin in canine endotoxin shock

dc.contributor.authorCronenwett, Jack L.en_US
dc.contributor.authorBaver-Neff, Beth S.en_US
dc.contributor.authorGrekin, Roger J.en_US
dc.contributor.authorSheagren, John N.en_US
dc.date.accessioned2006-04-07T19:23:28Z
dc.date.available2006-04-07T19:23:28Z
dc.date.issued1986-12en_US
dc.identifier.citationCronenwett, Jack L., Baver-Neff, Beth S., Grekin, Roger J., Sheagren, John N. (1986/12)."The role of endorphins and vasopressin in canine endotoxin shock." Journal of Surgical Research 41(6): 609-619. <http://hdl.handle.net/2027.42/25963>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WM6-4BNF019-148/2/bcc8f8c41afdd33fb6444a7be4f6ddb8en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25963
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2946895&dopt=citationen_US
dc.description.abstractChemical antagonists were used to assess the role of [beta]-endorphin and arginine-vasopressin (AVP) in canine endotoxin shock. Fifteen awake dogs were given Escherichia coli endotoxin IV. Within 5 min, CO decreased to 28%, LV dP/dt to 46%, and MAP to 52% of baseline. Fifteen minutes after endotoxin, five dogs each received naloxone, AVP antagonist, or no treatment. Control (untreated) animals exhibited persistent cardiovascular depression, with CO 49%, LV dP/dt 69%, and MAP 91% of baseline after 45 min. Naloxone improved CO to 69%, LV dP/dt to 94%, and MAP to 91% by 30 min after treatment. AVP blockade improved CO to 105%, LV dP/dt to 10%, and MAP to 95% of baseline by 30 min after treatment, and caused significant tachycardia. Plasma cortisol and AVP increased markedly in all groups after endotoxin administration. AVP antagonist treatment increased mean survival from 1.4 to 4 days. These data suggest that abnormally elevated AVP contributes to cardiovascular depression in canine endotoxin shock and that AVP blockade is therapeutic in the animal model studied.en_US
dc.format.extent1001423 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe role of endorphins and vasopressin in canine endotoxin shocken_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, the Veterans Administration Medical Center and the University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Surgery, the Veterans Administration Medical Center and the University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Medicine, the Veterans Administration Medical Center and the University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Medicine, the Veterans Administration Medical Center and the University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid2946895en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25963/1/0000029.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-4804(86)90086-7en_US
dc.identifier.sourceJournal of Surgical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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