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The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain

dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorChen, Ronnien_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2006-04-07T19:25:12Z
dc.date.available2006-04-07T19:25:12Z
dc.date.issued1986-10-30en_US
dc.identifier.citationSilverstein, Faye S., Chen, Ronni, Johnston, Michael V. (1986/10/30)."The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain." Neuroscience Letters 71(1): 13-18. <http://hdl.handle.net/2027.42/26009>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485RKNF-DD/2/0ce722ce584134329c9d6b0a31424ef0en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26009
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3024070&dopt=citationen_US
dc.description.abstractTo assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l [mu]l) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain.en_US
dc.format.extent414613 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.en_US
dc.contributor.affiliationumCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.en_US
dc.identifier.pmid3024070en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26009/1/0000076.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(86)90249-1en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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