Human placental glutathione S-transferase-mediated metabolism of methyl parathion
dc.contributor.author | Radulovic, Louis L. | en_US |
dc.contributor.author | LaFerla, John J. | en_US |
dc.contributor.author | Kulkarni, Arun P. | en_US |
dc.date.accessioned | 2006-04-07T19:25:21Z | |
dc.date.available | 2006-04-07T19:25:21Z | |
dc.date.issued | 1986-10-15 | en_US |
dc.identifier.citation | Radulovic, Louis L., LaFerla, John J., Kulkarni, Arun P. (1986/10/15)."Human placental glutathione S-transferase-mediated metabolism of methyl parathion." Biochemical Pharmacology 35(20): 3473-3480. <http://hdl.handle.net/2027.42/26013> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4P-4777X31-1D6/2/336a9dd874323495db0d49715cbbfe27 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26013 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3768034&dopt=citation | en_US |
dc.description.abstract | The ability of human placental glutathione S-transferase (GSHTr) to metabolize methyl parathion (MeP) was examined. MeP was found to be a substrate for both partially purified pre-term and highly purified term placental GSHTr. The characterization of the reaction by high performance liquid chromatography revealed the presence of desmethyl parathion (DesMeP) as the sole metabolite. Term placental GSHTr activity towards MeP ranged from 2.22 to 3.53 nmoles DesMeP formed [middle dot] min-1 [middle dot] mg-1 while an activity of 0.60 to 1.12 nmoles DesMeP formed [middle dot] min-1 [middle dot] mg-1 was observed with the pre-term placental enzyme. The absence of the O-dearylation reaction by pre-term and term placental GSHTr represents a major species- and/or tissue-specific difference. | en_US |
dc.format.extent | 568392 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Human placental glutathione S-transferase-mediated metabolism of methyl parathion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, School of Medicine, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 3768034 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26013/1/0000080.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-2952(86)90614-3 | en_US |
dc.identifier.source | Biochemical Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.