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Kappa receptor mediated opioid dependence in rhesus monkeys

dc.contributor.authorGmerek, Debra E.en_US
dc.contributor.authorWoods, James H.en_US
dc.date.accessioned2006-04-07T19:26:31Z
dc.date.available2006-04-07T19:26:31Z
dc.date.issued1986-09-15en_US
dc.identifier.citationGmerek, Debra E., Woods, James H. (1986/09/15)."Kappa receptor mediated opioid dependence in rhesus monkeys." Life Sciences 39(11): 987-992. <http://hdl.handle.net/2027.42/26046>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-4754DFX-1TY/2/9ebf55ddf4d0cf3a4b23d50608d0784den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26046
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3018406&dopt=citationen_US
dc.description.abstractThe kappa receptor-selective agonist U-50, 488 was administered chronically to rhesus monkeys. Tolerance developed to the overt behavioral effects of U-50, 488 without cross-tolerance to morphine. Withdrawal behaviors produced by deprivation, naloxone or quadazocine administration in U-50, 488-dependent monkeys consisted of hyperactivity, excessive grooming, and yawning. The syndrome was suppressed in a dose-related manner by a kappa agonist, ethylketazocine, but not by doses of morphine that suppressed its own withdrawal. The mu-selective antagonist, beta-funaltrexamine, at doses which are active in morphine-dependent monkeys, did not precipitate withdrawal in U50, 488-dependent monkeys. Dependence, which is the result of activity at the kappa receptor, was distinct from morphine dependence.en_US
dc.format.extent337908 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleKappa receptor mediated opioid dependence in rhesus monkeysen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, M6322 Medical Science Building I, University of Michigan Medical School, Ann Arbor, MI 48109-0010, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, M6322 Medical Science Building I, University of Michigan Medical School, Ann Arbor, MI 48109-0010, USAen_US
dc.identifier.pmid3018406en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26046/1/0000119.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(86)90287-0en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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