Kappa receptor mediated opioid dependence in rhesus monkeys
dc.contributor.author | Gmerek, Debra E. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.date.accessioned | 2006-04-07T19:26:31Z | |
dc.date.available | 2006-04-07T19:26:31Z | |
dc.date.issued | 1986-09-15 | en_US |
dc.identifier.citation | Gmerek, Debra E., Woods, James H. (1986/09/15)."Kappa receptor mediated opioid dependence in rhesus monkeys." Life Sciences 39(11): 987-992. <http://hdl.handle.net/2027.42/26046> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4754DFX-1TY/2/9ebf55ddf4d0cf3a4b23d50608d0784d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26046 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3018406&dopt=citation | en_US |
dc.description.abstract | The kappa receptor-selective agonist U-50, 488 was administered chronically to rhesus monkeys. Tolerance developed to the overt behavioral effects of U-50, 488 without cross-tolerance to morphine. Withdrawal behaviors produced by deprivation, naloxone or quadazocine administration in U-50, 488-dependent monkeys consisted of hyperactivity, excessive grooming, and yawning. The syndrome was suppressed in a dose-related manner by a kappa agonist, ethylketazocine, but not by doses of morphine that suppressed its own withdrawal. The mu-selective antagonist, beta-funaltrexamine, at doses which are active in morphine-dependent monkeys, did not precipitate withdrawal in U50, 488-dependent monkeys. Dependence, which is the result of activity at the kappa receptor, was distinct from morphine dependence. | en_US |
dc.format.extent | 337908 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Kappa receptor mediated opioid dependence in rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M6322 Medical Science Building I, University of Michigan Medical School, Ann Arbor, MI 48109-0010, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M6322 Medical Science Building I, University of Michigan Medical School, Ann Arbor, MI 48109-0010, USA | en_US |
dc.identifier.pmid | 3018406 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26046/1/0000119.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(86)90287-0 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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